Journal article
Acute effects of doxorubicin on human left ventricular systolic and diastolic function
The American heart journal, Vol.118(5), pp.979-982
1989
DOI: 10.1016/0002-8703(89)90233-0
PMID: 2816709
Abstract
Although the long-term cardiotoxic effects of cumulative doses of doxorubicin are well established, the short-term effects on cardiac function are uncertain. Therefore we examined the short-term effects of doxorubicin on left ventricular systolic and diastolic function following a total of 56 doses of doxorubicin in 15 patients with normal resting left ventricular function. Resting radionuclide ventriculography was performed 1 hour before and 4 hours after each dose of doxorubicin. Left ventricular ejection fraction increased significantly from 64 ± 1% to 67 ± 1% (
p < 0.001) after doxorubicin. In addition, peak ejection rate (
p < 0.005) and peak filling rate (
p < 0.0005) increased significantly following short-term doxorubicin administration. There was no relationship between either the individual or cumulative dose of doxorubicin and the acute ejection fraction, peak ejection rate, or peak filling rate response. Our data suggest that doxorubicin acutely increases left ventricular systolic and diastolic function.
Details
- Title: Subtitle
- Acute effects of doxorubicin on human left ventricular systolic and diastolic function
- Creators
- Kenneth A Brown - Cardiology Unit, Department of Medicine, University of Vermont College of Medicine, Burlington, Vt. USAAlton J Blow - Cardiology Unit, Department of Medicine, University of Vermont College of Medicine, Burlington, Vt. USARobert M Weiss - Cardiology Unit, Department of Medicine, University of Vermont College of Medicine, Burlington, Vt. USAJames A Stewart - Cardiology Unit, Department of Medicine, University of Vermont College of Medicine, Burlington, Vt. USA
- Resource Type
- Journal article
- Publication Details
- The American heart journal, Vol.118(5), pp.979-982
- Publisher
- Mosby, Inc
- DOI
- 10.1016/0002-8703(89)90233-0
- PMID
- 2816709
- ISSN
- 0002-8703
- eISSN
- 1097-6744
- Language
- English
- Date published
- 1989
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094493702771
Metrics
25 Record Views