Journal article
Acute hemodynamic responses to intravenous and intra-arterial guanethidine
The American journal of physiology, Vol.201(3), pp.462-466
09/01/1961
DOI: 10.1152/ajplegacy.1961.201.3.462
PMID: 13680932
Abstract
Intravenous administration of guanethidine to dogs causes an abrupt fall in systemic arterial pressure which is followed by a sustained increase. These studies were made to determine the nature of this biphasic response. Observations were made on dogs before and at frequent intervals after guanethidine was given. A fall in arterial pressure, an increase in cardiac output, and a decrease in peripheral resistance were observed within 10 sec; these changes lasted 40–50 sec. After the depressor phase, blood pressure and stroke volume increased while resistance returned to control levels. These acute changes subsided within 10–15 min. Ganglionic blockade augmented the pressor response and adrenergic blockade reduced it. Intra-arterial injection of guanethidine into perfused denervated forelegs caused brief vasodilatation followed by vasoconstriction. This response was qualitatively different from that seen with intra-arterial injection of norepinephrine. The results support indirectly the hypothesis that the systemic pressor response is caused by circulating catecholamines. The results demonstrate also that the drug has a local vasodilator action on the blood vessels of the foreleg.
Details
- Title: Subtitle
- Acute hemodynamic responses to intravenous and intra-arterial guanethidine
- Creators
- Francois M Abboud - Hemodynamic Laboratory, Cardiovascular Research Laboratories, Department of Internal Medicine, State University of Iowa College of Medicine, Iowa City, IowaJohn W Eckstein - Hemodynamic Laboratory, Cardiovascular Research Laboratories, Department of Internal Medicine, State University of Iowa College of Medicine, Iowa City, IowaSantiago A Pereda - Hemodynamic Laboratory, Cardiovascular Research Laboratories, Department of Internal Medicine, State University of Iowa College of Medicine, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.201(3), pp.462-466
- DOI
- 10.1152/ajplegacy.1961.201.3.462
- PMID
- 13680932
- NLM abbreviation
- Am J Physiol
- ISSN
- 0002-9513
- eISSN
- 2163-5773
- Publisher
- American Physiological Society
- Language
- English
- Date published
- 09/01/1961
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025471202771
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