Journal article
Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database
Pediatric nephrology (Berlin, West), Vol.34(1), pp.169-176
01/01/2019
DOI: 10.1007/s00467-018-4068-2
PMCID: PMC6986688
PMID: 30155763
Abstract
Acute kidney injury (AKI) is common in neonatal encephalopathy (NE) and is associated with worse outcomes. Our objectives were to determine the incidence, risk factors, and outcomes of AKI in infants with NE.
We performed a retrospective analysis of infants ≥ 34 weeks' gestational age with a diagnosis of NE from the Analysis of Worldwide Acute Kidney injury Epidemiology in Neonates (AWAKEN) database. AKI was defined using the modified Kidney Disease Improving Global Outcomes criteria. Perinatal and postnatal factors were evaluated. Multivariate logistic and linear regressions were performed.
One hundred and thirteen patients with NE were included. 41.6% (47) developed AKI. Being born outside the admitting institution (OR 4.3; 95% CI 1.2-14.8; p = 0.02), intrauterine growth restriction (OR 10.3, 95% CI 1.1-100.5; p = 0.04), and meconium at delivery (OR 2.8, 95% CI 1.04-7.7; p = 0.04) conferred increased odds of AKI. After controlling for confounders, infants with AKI stayed in the hospital an average of 8.5 days longer than infants without AKI (95% CI 0.79-16.2 days; p = 0.03).
In this multi-national analysis, several important perinatal factors were associated with AKI and infants with both NE and AKI had longer length of stay than NE alone. Future research aimed at early AKI detection, renoprotective management strategies, and understanding the long-term renal consequences is warranted in this high-risk group of patients.
Details
- Title: Subtitle
- Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database
- Creators
- Megan J Kirkley - University of Colorado, Anschutz Medical Campus 13123 E 16th Avenue, B158, Aurora, CO, 80045, USA. Megan.Kirkley@childrenscolorado.orgLouis Boohaker - University of Alabama at BirminghamRussell Griffin - University of Alabama at BirminghamDanielle E Soranno - University of Colorado BoulderJason Gien - University of Colorado DenverDavid Askenazi - University of AlabamaKatja M Gist - Children's Hospital ColoradoNeonatal Kidney Collaborative (NKC)
- Contributors
- Jennifer G Jetton (Contributor)Tarah T Colaizy (Contributor) - University of Iowa, NeonatologyJonathan M Klein (Contributor) - University of Iowa, Neonatology
- Resource Type
- Journal article
- Publication Details
- Pediatric nephrology (Berlin, West), Vol.34(1), pp.169-176
- DOI
- 10.1007/s00467-018-4068-2
- PMID
- 30155763
- PMCID
- PMC6986688
- ISSN
- 0931-041X
- eISSN
- 1432-198X
- Grant note
- UL1TR001417 / NIH HHS R01 DK103608 / NIDDK NIH HHS U54 TR001356 / NCATS NIH HHS UL1 TR001449 / NCATS NIH HHS K08 DK109226 / NIDDK NIH HHS UL1 TR001417 / NCATS NIH HHS R01 FD005092 / FDA HHS
- Language
- English
- Date published
- 01/01/2019
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354152802771
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