Journal article
Acute marijuana effects on rCBF and cognition: a PET study
Neuroreport, Vol.11(17), pp.3835-3840
11/27/2000
DOI: 10.1097/00001756-200011270-00047
PMID: 11117500
Abstract
The effects of smoking marijuana on cognition and brain function were assessed with PET using H2(15)O. Regional cerebral blood flow (rCBF) was measured in five recreational users before and after smoking a marijuana cigarette, as they repeatedly performed an auditory attention task. Blood flow increased following smoking in a number of paralimbic brain regions (e.g. orbital frontal lobes, insula, temporal poles) and in anterior cingulate and cerebellum. Large reductions in rCBF were observed in temporal lobe regions that are sensitive to auditory attention effects. Brain regions showing increased rCBF may mediate the intoxicating and mood-related effects of smoking marijuana, whereas reduction of task-related rCBF in temporal lobe cortices may account for the impaired cognitive functions associated with acute intoxication.
Details
- Title: Subtitle
- Acute marijuana effects on rCBF and cognition: a PET study
- Creators
- D S O'Leary - Mental Health Clinical Research Center, University of Iowa, Iowa City 52242, USAR I BlockM FlaumS K SchultzL L Boles PontoG L WatkinsR R HurtigN C AndreasenR D Hichwa
- Resource Type
- Journal article
- Publication Details
- Neuroreport, Vol.11(17), pp.3835-3840
- Publisher
- England
- DOI
- 10.1097/00001756-200011270-00047
- PMID
- 11117500
- ISSN
- 0959-4965
- eISSN
- 1473-558X
- Grant note
- DA10551 / NIDA NIH HHS
- Language
- English
- Date published
- 11/27/2000
- Academic Unit
- Radiology; Communication Sciences and Disorders; Psychiatry; Research Administration; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology; Anesthesia; Internal Medicine
- Record Identifier
- 9984003913502771
Metrics
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