Journal article
Acute myelogenous leukemia with the t(3;12)(q26;p13) translocation: Case report and review of the literature
American journal of hematology, Vol.72(2), pp.135-137
02/2003
DOI: 10.1002/ajh.10248
PMID: 12555218
Abstract
Translocations involving the EVI1/MDS1 gene at 3q26 and the TEL gene at 12p13 are comparatively common in acute leukemia, but a translocation between the two genes has been reported only in a handful of cases. We report an additional case of acute myelogenous leukemia (AML) preceded by a myelodysplastic syndrome (MDS) with the translocation t(3;12)(q26;p13) in a 36-year-old woman. The translocation was present early in the disease and long before the MDS progressed to AML 3 years after diagnosis. At the time of progression to AML, an additional chromosomal abnormality, a monosomy 22, was discovered. The patient was treated with the protocol MAQ, which comprised mitoxantrone, aracytine, and quinine, as her blasts expressed the p-glycoprotein, but she failed to obtain remission. A second treatment with the same protocol resulted in only minimal response. The patient was treated again with high-dose Ara-C and idarubicine in an attempt to achieve a response before allogeneic unrelated transplantation, but she did not respond to the treatment and died shortly thereafter. A review of the literature revealed 12 other cases of the t(3;12)(q26;p13) translocation. Characteristics of those cases are reviewed in this article.
Details
- Title: Subtitle
- Acute myelogenous leukemia with the t(3;12)(q26;p13) translocation: Case report and review of the literature
- Creators
- Loannis A Voutsadakis - Institut Gustave RoussyNatacha Maillard - Institut Gustave Roussy
- Resource Type
- Journal article
- Publication Details
- American journal of hematology, Vol.72(2), pp.135-137
- Publisher
- Wiley-Liss
- DOI
- 10.1002/ajh.10248
- PMID
- 12555218
- ISSN
- 0361-8609
- eISSN
- 1096-8652
- Number of pages
- 3
- Language
- English
- Date published
- 02/2003
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806601702771
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