Journal article
Acute onset nitrofurantoin-induced autoimmune hepatitis after urinary tract infection treatment
Clinical case reports, Vol.12(6), p.e9050
06/11/2024
DOI: 10.1002/ccr3.9050
PMCID: PMC11166554
PMID: 38868111
Appears in UI Libraries Support Open Access
Abstract
Various drugs can induce immune-mediated liver damage and in rare instances may lead to autoimmune hepatitis. Here we report an 84-year-old woman who developed autoimmune hepatitis less than 3 weeks after treatment for urinary tract infection with the antibiotic nitrofurantoin. She presented with jaundice, right upper quadrant abdominal pain, nausea, and vomiting. In the absence of a history of an autoimmune disorder or elevated liver enzymes in the past; elevated liver enzymes after a short course of Nitrofurantoin and the presence of smooth muscle antibodies strongly suggested autoimmune hepatitis, which was confirmed through biopsy sample analysis. The patient scored 7 points on the Naranjo adverse reaction probability scale. The patient's rapid recovery within 1 month of prednisone therapy supports the association of liver damage with nitrofurantoin use.
Details
- Title: Subtitle
- Acute onset nitrofurantoin-induced autoimmune hepatitis after urinary tract infection treatment
- Creators
- Ammad Javaid Chaudhary - Henry Ford HospitalMuhammad Zarrar Khan - Henry Ford HospitalAbdullah Sohail - University of Iowa, Internal MedicineSyed Murtaza Haider Zaidi - King Edward Medical UniversityEric Denha - Wayne State UniversityDeepak Venkat - Henry Ford Hospital
- Resource Type
- Journal article
- Publication Details
- Clinical case reports, Vol.12(6), p.e9050
- Publisher
- Wiley
- DOI
- 10.1002/ccr3.9050
- PMID
- 38868111
- PMCID
- PMC11166554
- ISSN
- 2050-0904
- eISSN
- 2050-0904
- Language
- English
- Date published
- 06/11/2024
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984644155402771
Metrics
11 Record Views