Journal article
Acute resetting of the carotid sinus baroreflex by aortic depressor nerve stimulation
The American journal of physiology, Vol.264(4 Pt 2), pp.H1215-H1222
04/1993
DOI: 10.1152/ajpheart.1993.264.4.H1215
PMID: 8476098
Abstract
The effect of prolonged aortic depressor nerve (ADN) stimulation on carotid sinus baroreflex regulation of arterial pressure (AP) and renal sympathetic nerve activity (RSNA) was examined in anesthetized rabbits. Ramp increases in carotid sinus pressure (CSP) were repeated before and after 5 min of bilateral ADN stimulation. One minute after ADN stimulation the curve relating AP to CSP had shifted up and to the right, characterized by significant increases (P < 0.05) in the maximum (91 +/- 2 to 101 +/- 3 mmHg; mean +/- SE), midpoint (118 +/- 7 to 125 +/- 8 mmHg CSP), and minimum (45 +/- 3 to 53 +/- 4 mmHg) of the AP reflex curve. There was a parallel shift downward of the curve relating RSNA to CSP, characterized by significant decreases in the maximum [100 +/- 0 to 66 +/- 8% of maximum control RSNA value (%max)], the range (90 +/- 2 to 59 +/- 8%max), and the gain (-1.0 +/- 0.2 to -0.5 +/- 0.1%max/mmHg) of the RSNA reflex curve. Values returned to control within 10 min of cessation of ADN stimulation. These results suggest that central neurons processing baroreflex information from one set of mechanoreceptors can be reset by convergent signals arising from another baroreceptor site.
Details
- Title: Subtitle
- Acute resetting of the carotid sinus baroreflex by aortic depressor nerve stimulation
- Creators
- L Hayward - Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242M HayR B Felder
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.264(4 Pt 2), pp.H1215-H1222
- Publisher
- United States
- DOI
- 10.1152/ajpheart.1993.264.4.H1215
- PMID
- 8476098
- ISSN
- 0002-9513
- eISSN
- 2163-5773
- Grant note
- HL-29302 / NHLBI NIH HHS HL-07121-15 / NHLBI NIH HHS HL-44546 / NHLBI NIH HHS
- Language
- English
- Date published
- 04/1993
- Academic Unit
- Iowa Neuroscience Institute; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984065478402771
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