Acute retinal necrosis caused by herpes simplex virus type 2 in children: reactivation of an undiagnosed latent neonatal herpes infection

Charles Grose

doi:10.1016/j.spen.2012.02.005

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Acute retinal necrosis caused by herpes simplex virus type 2 in children: reactivation of an undiagnosed latent neonatal herpes infection

Journal article

Peer reviewed

Acute retinal necrosis caused by herpes simplex virus type 2 in children: reactivation of an undiagnosed latent neonatal herpes infection

Charles Grose

Seminars in pediatric neurology, Vol.19(3), pp.115-118

09/2012

DOI: 10.1016/j.spen.2012.02.005

PMCID: PMC3419358

PMID: 22889540

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https://www.ncbi.nlm.nih.gov/pmc/articles/3419358View

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Abstract

Herpes simplex virus type 2 (HSV-2) is known to cause acute retinal necrosis (ARN). The availability of HSV-2-specific polymerase chain reaction tests for diagnostic analysis has greatly increased our ability to discriminate ARN caused by HSV-2 from ARN caused by either herpes simplex virus type 1 or varicella zoster virus (VZV). Of great interest, HSV-2 appears to be the most common cause of viral ARN in children and adolescents. Although a few children with ARN are known to have had neonatally acquired herpes infection, most children lack a history of known herpes disease. Thus, the origin of the HSV-2 infection is a mystery. The hypothesis of this review is that HSV-2 ARN in children and adolescents may be the first sign of a previously undiagnosed and asymptomatic neonatal HSV-2 infection, which has reactivated several years later from latency in a cranial nerve and entered the retina. The review brings together 7 previously published ARN cases, plus one new case is added. Thus, this review also expands the spectrum of complications from neonatal HSV-2 infection.

Pregnancy Complications, Infectious - virology

Herpes Simplex - diagnosis

Antiviral Agents - therapeutic use

Retinal Necrosis Syndrome, Acute - drug therapy

Virus Latency

Humans

Child, Preschool

Male

Herpesvirus 3, Human - genetics

Herpesvirus 2, Human - genetics

Herpes Simplex - virology

Adolescent

Female

Herpes Simplex - complications

Herpesvirus 1, Human - genetics

Herpesvirus 2, Human - physiology

Retinal Necrosis Syndrome, Acute - virology

Child

Herpesvirus 2, Human - pathogenicity

Virus Activation

Retinal Necrosis Syndrome, Acute - diagnosis

Pregnancy Complications, Infectious - diagnosis

Details

Title: Subtitle: Acute retinal necrosis caused by herpes simplex virus type 2 in children: reactivation of an undiagnosed latent neonatal herpes infection
Creators: Charles Grose - Division of Infectious Diseases, Department of Pediatrics, University of Iowa Children's Hospital, Iowa City, IA, USA. charles-grose@uiowa.edu
Resource Type: Journal article
Publication Details: Seminars in pediatric neurology, Vol.19(3), pp.115-118
DOI: 10.1016/j.spen.2012.02.005
PMID: 22889540
PMCID: PMC3419358
NLM abbreviation: Semin Pediatr Neurol
ISSN: 1071-9091
eISSN: 1558-0776
Grant note: R01 AI089716 / NIAID NIH HHS
Language: English
Date published: 09/2012
Academic Unit: Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
Record Identifier: 9984093229502771

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21 Times Cited - Web of Science