Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II-induced microcirculatory changes in a model of primary hypertension

Felipe Freitas; Vanessa Estato; Patricia Reis; Hugo C Castro-Faria-Neto; Vinícius Carvalho; Rafael Torres; Marcos A Lessa; Eduardo Tibirica

doi:10.1111/micc.12416

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Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II-induced microcirculatory changes in a model of primary hypertension

Journal article

Peer reviewed

Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II-induced microcirculatory changes in a model of primary hypertension

Felipe Freitas, Vanessa Estato, Patricia Reis, Hugo C Castro-Faria-Neto, Vinícius Carvalho, Rafael Torres, Marcos A Lessa and Eduardo Tibirica

Microcirculation (New York, N.Y. 1994), Vol.24(8), e12416

11/2017

DOI: 10.1111/micc.12416

PMID: 28865157

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Abstract

We investigated the acute effects of SIM on cerebral microvascular rarefaction and dysfunction in SHRs. Male WKY and SHRs were divided into 4 groups of 8 animals each: WKY-CTL and SHR-CTL, treated with 0.9% saline; and WKY+SIM and SHR+SIM, treated with SIM (30 mg/kg/d) for 3 days by gavage. Cerebral FCD was assessed by intravital fluorescence videomicroscopy. mCBF before and after administration within the cranial window of angiotensin II (1 μmol L ) was investigated using laser speckle contrast imaging. Cerebral FCD was reduced in SHR-CTL compared to WKY-CTL (P < .05). SIM increased cerebral FCD in SHRs compared to SHR-CTL (P < .05). The mCBF was reduced in SHR-CTL compared to WKY-CTL (P < .05), and SIM increased mCBF compared with SHR-CTL (P < .05). Angiotensin II elicited a reduction of mCBF in SHR-CTL and increased mCBF in WKY-CTL (SHR-CTL -13.53 ± 2% vs WKY-CTL +13.74 ± 4%; P < .001), which was attenuated in SHRs treated with SIM (SHR+SIM -6.7 ± 1% vs SHR-CTL -13.53 ± 2%; P < .01). The antihypertensive effect of SIM is associated with an improvement in cerebral microvascular perfusion and capillary density that may help to prevent hypertension-induced cerebrovascular damage independent of cholesterol-lowering.

Angiotensin II - pharmacology

Animals

Cerebrovascular Circulation - drug effects

Disease Models, Animal

Hypertension - drug therapy

Hypertension - pathology

Hypertension - physiopathology

Male

Microcirculation - drug effects

Rats

Rats, Inbred SHR

Rats, Inbred WKY

Simvastatin - pharmacology

Details

Title: Subtitle: Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II-induced microcirculatory changes in a model of primary hypertension
Creators: Felipe Freitas - Fundação Oswaldo Cruz
Vanessa Estato - Fundação Oswaldo Cruz
Patricia Reis - Fundação Oswaldo Cruz
Hugo C Castro-Faria-Neto - Estácio
Vinícius Carvalho - Fundação Oswaldo Cruz
Rafael Torres - Fundação Oswaldo Cruz
Marcos A Lessa - University of Iowa, Anesthesia
Eduardo Tibirica - Fundação Oswaldo Cruz
Resource Type: Journal article
Publication Details: Microcirculation (New York, N.Y. 1994), Vol.24(8), e12416
DOI: 10.1111/micc.12416
PMID: 28865157
ISSN: 1073-9688
eISSN: 1549-8719
Language: English
Date published: 11/2017
Academic Unit: Anesthesia
Record Identifier: 9984656594102771

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