Journal article
Acyclovir in the Treatment of Recurrent Respiratory Papillomatosis: A Pilot Study
Annals of otology, rhinology & laryngology, Vol.103(4), pp.301-305
04/1994
DOI: 10.1177/000348949410300407
PMID: 8154772
Abstract
Six patients with severe, recalcitrant, juvenile-onset recurrent respiratory papillomatosis were treated with 7 independent trials of acyclovir. In 2 trials, patients received acyclovir in place of interferon-α; the remaining 5 trials were in patients not otherwise receiving chemotherapy. Quantitative analysis of overall disease extent, laryngeal involvement, and degree of glottic obstruction for the 6 months prior to acyclovir administration and during acyclovir administration demonstrated a statistically significant decrease in all parameters evaluated in those patients who were otherwise unmedicated. The 2 patients who discontinued interferon-α immediately prior to beginning acyclovir demonstrated worsening disease, consistent with the well-recognized rebound phenomenon associated with stopping interferon. This study suggests that acyclovir decreases the extent of respiratory papillomatosis in patients with recalcitrant disease. The beneficial effect of acyclovir appears to be insufficient to counteract the rebound of disease when interferon is stopped abruptly.
Details
- Title: Subtitle
- Acyclovir in the Treatment of Recurrent Respiratory Papillomatosis: A Pilot Study
- Creators
- Donald R Endres - Iowa City, IowaDiane Burke - Iowa City, IowaNancy M Bauman - Iowa City, IowaRichard J. H Smith - Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Annals of otology, rhinology & laryngology, Vol.103(4), pp.301-305
- DOI
- 10.1177/000348949410300407
- PMID
- 8154772
- NLM abbreviation
- Ann Otol Rhinol Laryngol
- ISSN
- 0003-4894
- eISSN
- 1943-572X
- Publisher
- SAGE Publications; Los Angeles, CA
- Language
- English
- Date published
- 04/1994
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006315602771
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