Journal article
Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum
Nature neuroscience, Vol.7(12), pp.1296-1298
11/14/2004
DOI: 10.1038/nn1348
PMID: 15543142
Abstract
Long-term potentiation (LTP) of granule cell-Purkinje cell synapses in the mouse cerebellum requires phosphorylation by protein kinase A of the active-zone protein RIM1α at Ser413. Here, we show that the adapter protein 14-3-3 readily binds phosphorylated Ser413 in RIM1α, and that presynaptic transfection with a dominant-negative 14-3-3η mutant, or a RIM1α mutant with enhanced 14-3-3 binding, inhibits LTP. Thus, RIM1α phosphorylation triggers presynaptic LTP in part through recruitment of 14-3-3 to phospho-Ser413-RIM1α.
Details
- Title: Subtitle
- Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum
- Creators
- Fatma Simsek-Duran - Eastern Virginia Medical SchoolDavid J Linden - Department of Neuroscience, Johns Hopkins University School of MedicineGyörgy Lonart - Department of Pathology & Anatomy, Eastern Virginia Medical School
- Resource Type
- Journal article
- Publication Details
- Nature neuroscience, Vol.7(12), pp.1296-1298
- DOI
- 10.1038/nn1348
- PMID
- 15543142
- ISSN
- 1097-6256
- eISSN
- 1546-1726
- Language
- English
- Date published
- 11/14/2004
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003478602771
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