Journal article
Adaptive Immune Response of Vγ2Vδ2+ T Cells During Mycobacterial Infections
Science (American Association for the Advancement of Science), Vol.295(5563), pp.2255-2258
03/22/2002
DOI: 10.1126/science.1068819
PMCID: PMC2872146
PMID: 11910108
Abstract
To examine the role of T cell receptor (TCR) in γδ T cells in adaptive immunity, a macaque model was used to follow Vγ2Vδ2
+
T cell responses to mycobacterial infections. These phosphoantigen-specific γδ T cells displayed major expansion during
Mycobacterium bovis
Bacille Calmette-Guérin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vγ2Vδ2
+
T cells were also seen during
Mycobacterium tuberculosis
infection of naïve and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vγ2Vδ2
+
T cells may contribute to adaptive immunity to mycobacterial infections.
Details
- Title: Subtitle
- Adaptive Immune Response of Vγ2Vδ2+ T Cells During Mycobacterial Infections
- Creators
- Craig T Morita - Division of Rheumatology, Department of Internal Medicine, and the Interdisciplinary Group on Immunology, University of Iowa, Iowa City, IA 52242, USAYun Shen - Tuberculosis Research Unit, Harvard Medical School, Boston, MA 02115, USADejiang Zhou - Tuberculosis Research Unit, Harvard Medical School, Boston, MA 02115, USALiyou Qiu - Tuberculosis Research Unit, Harvard Medical School, Boston, MA 02115, USAXioamin Lai - Tuberculosis Research Unit, Harvard Medical School, Boston, MA 02115, USAMeredith Simon - New England Regional Primate Research Center, Southboro, MA 01772, USALing Shen - Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USAZhongchen Kou - Tuberculosis Research Unit, Harvard Medical School, Boston, MA 02115, USAQifan Wang - Tuberculosis Research Unit, Harvard Medical School, Boston, MA 02115, USALiming Jiang - Tuberculosis Research Unit, Harvard Medical School, Boston, MA 02115, USAJim Estep - Battelle Medical Research and Evaluation Facility, Battelle Memorial Institute, Columbus, Ohio 43201, USARobert Hunt - Battelle Medical Research and Evaluation Facility, Battelle Memorial Institute, Columbus, Ohio 43201, USAMichelle Clagett - Battelle Medical Research and Evaluation Facility, Battelle Memorial Institute, Columbus, Ohio 43201, USAPrabhat K Sehgal - New England Regional Primate Research Center, Southboro, MA 01772, USAYunyaun Li - Tuberculosis Research Unit, Harvard Medical School, Boston, MA 02115, USAXuejun Zeng - Tuberculosis Research Unit, Harvard Medical School, Boston, MA 02115, USAMichael B Brenner - Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USANorman L Letvin - Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USAZheng W Chen - Tuberculosis Research Unit, Harvard Medical School, Boston, MA 02115, USA
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.295(5563), pp.2255-2258
- DOI
- 10.1126/science.1068819
- PMID
- 11910108
- PMCID
- PMC2872146
- NLM abbreviation
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 03/22/2002
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094876702771
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