Journal article
Adenosine-A1 receptor agonist induced hyperalgesic priming type II
Pain (Amsterdam), Vol.157(3), pp.698-709
03/01/2016
DOI: 10.1097/j.pain.0000000000000421
PMID: 26588695
Abstract
We have recently shown that repeated exposure of the peripheral terminal of the primary afferent nociceptor to the mu-opioid receptor (MOR) agonist DAMGO ([D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin acetate salt) induces a model of transition to chronic pain that we have termed type II hyperalgesic priming. Similar to type I hyperalgesic priming, there is a markedly prolonged response to subsequent administration of proalgesic cytokines, prototypically prostaglandin E2 (PGE2). However, type II hyperalgesic priming differs from type I in being rapidly induced, protein kinase A (PKA), rather than PKCε dependent, not reversed by a protein translation inhibitor, occurring in female as well as in male rats, and isolectin B4-negative neuron dependent. We report that, as with the repeated injection of a MOR agonist, the repeated administration of an agonist at the A1-adenosine receptor, also a Gi-protein coupled receptor, N6-cyclopentyladenosine (CPA), also produces priming similar to DAMGO-induced type II hyperalgesic priming. In this study, we demonstrate that priming induced by repeated exposure to this A1-adenosine receptor agonist shares the same mechanisms, as MOR-agonist induced priming. However, the prolongation of PGE2 hyperalgesia induced by repeated administration of CPA depends on G-protein αi subunit activation, differently from DAMGO-induced type II priming, in which it depends on the β/γ subunit. These data implicate a novel form of Gi-protein signaling pathway in the type II hyperalgesic priming induced by repeated administration of an agonist at A1-adenosine receptor to the peripheral terminal of the nociceptor.
Details
- Title: Subtitle
- Adenosine-A1 receptor agonist induced hyperalgesic priming type II
- Creators
- Dioneia Araldi - University of California, San FranciscoLuiz F. Ferrari - University of California, San FranciscoJon D. Levine - University of California, San Francisco
- Resource Type
- Journal article
- Publication Details
- Pain (Amsterdam), Vol.157(3), pp.698-709
- DOI
- 10.1097/j.pain.0000000000000421
- PMID
- 26588695
- NLM abbreviation
- Pain
- ISSN
- 0304-3959
- eISSN
- 1872-6623
- Number of pages
- 12
- Grant note
- R01NS084545 / National Institute of Neurological Disorders and Stroke (http://data.elsevier.com/vocabulary/SciValFunders/100000065) National Institutes of Health (http://data.elsevier.com/vocabulary/SciValFunders/100000002) NS084545 / National Institutes of Health
- Language
- English
- Date published
- 03/01/2016
- Academic Unit
- Neuroscience and Pharmacology
- Record Identifier
- 9985177946802771
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