Adenoviral infection decreases mortality from lipopolysaccharide-induced liver failure via induction of TNF-alpha tolerance

Timur O Yarovinsky; Linda S Powers; Noah S Butler; Mary A Bradford; Martha M Monick; Gary W Hunninghake

doi:10.4049/jimmunol.171.5.2453

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Adenoviral infection decreases mortality from lipopolysaccharide-induced liver failure via induction of TNF-alpha tolerance

Journal article

Peer reviewed

Adenoviral infection decreases mortality from lipopolysaccharide-induced liver failure via induction of TNF-alpha tolerance

Timur O Yarovinsky, Linda S Powers, Noah S Butler, Mary A Bradford, Martha M Monick and Gary W Hunninghake

The Journal of immunology (1950), Vol.171(5), pp.2453-2460

09/01/2003

DOI: 10.4049/jimmunol.171.5.2453

PMID: 12928393

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Abstract

Effects of adenoviral infection on in vivo responses to LPS mediated by TNF-alpha were evaluated in a murine model. Adenovirus-infected mice showed decreased mortality from fulminant hepatitis induced by administration of LPS or staphylococcal enterotoxin B in the presence of D-galactosamine. Importantly, TNF-alpha resistance genes within adenoviral E3 region were not required, because E1,E3-deleted vectors showed similar effects. Adenovirus-infected mice exhibited higher TNF-alpha levels after LPS stimulation, no difference in TNFR1 expression, and similar mortality from Fas-induced fulminant hepatitis. Decreased production of IL-6 and KC in response to exogenous TNF-alpha, in addition to protection from TNF-alpha, suggested that adenoviral infection results in TNF-alpha tolerance.

Liver - pathology

Injections, Intravenous

Liver Failure - mortality

Antigens, CD - biosynthesis

Immune Tolerance - physiology

Humans

Liver Failure - pathology

Liver Failure - immunology

fas Receptor - immunology

Liver - immunology

Female

Mice, Inbred DBA

Disease Models, Animal

Cell Line

Lipopolysaccharides - toxicity

Adenoviruses, Human - immunology

Liver - metabolism

Mice, Inbred C57BL

Receptors, Tumor Necrosis Factor, Type I

Injections, Intraperitoneal

Adenovirus Infections, Human - immunology

Adenovirus Infections, Human - mortality

Animals

Up-Regulation - immunology

Autoantibodies - toxicity

Survival Analysis

Tumor Necrosis Factor-alpha - physiology

Receptors, Tumor Necrosis Factor - biosynthesis

Liver Failure - prevention & control

Mice

Tumor Necrosis Factor-alpha - biosynthesis

Galactosamine - toxicity

Details

Title: Subtitle: Adenoviral infection decreases mortality from lipopolysaccharide-induced liver failure via induction of TNF-alpha tolerance
Creators: Timur O Yarovinsky - Department of Internal Medicine, Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa, 100 EMRB, Iowa City, IA 52242, USA. timur-yarovinsky@uiowa.edu
Linda S Powers
Noah S Butler
Mary A Bradford
Martha M Monick
Gary W Hunninghake
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.171(5), pp.2453-2460
DOI: 10.4049/jimmunol.171.5.2453
PMID: 12928393
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Publisher: United States
Grant note: ES 09607 / NIEHS NIH HHS HL 60316 / NHLBI NIH HHS
Language: English
Date published: 09/01/2003
Academic Unit: Microbiology and Immunology; Internal Medicine
Record Identifier: 9984002384902771

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