Journal article
Adenovirus Fiber Disrupts CAR-Mediated Intercellular Adhesion Allowing Virus Escape
Cell (Cambridge), Vol.110(6), pp.789-799
2002
DOI: 10.1016/S0092-8674(02)00912-1
PMID: 12297051
Abstract
Adenovirus binds its receptor (CAR), enters cells, and replicates. It must then escape to the environment to infect a new host. We found that following infection, human airway epithelia first released adenovirus to the basolateral surface. Virus then traveled between epithelial cells to emerge on the apical surface. Adenovirus fiber protein, which is produced during viral replication, facilitated apical escape. Fiber binds CAR, which sits on the basolateral membrane where it maintains tight junction integrity. When fiber bound CAR, it disrupted junctional integrity, allowing virus to filter between the cells and emerge apically. Thus, adenovirus exploits its receptor for two important but distinct steps in its life cycle: entry into host cells and escape across epithelial barriers to the environment.
Details
- Title: Subtitle
- Adenovirus Fiber Disrupts CAR-Mediated Intercellular Adhesion Allowing Virus Escape
- Creators
- Robert W Walters - Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242 USAPaul Freimuth - Biology Department, Brookhaven National Laboratory, Upton, NY 11973 USAThomas O Moninger - Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242 USAIngrid Ganske - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242 USAJoseph Zabner - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242 USAMichael J Welsh - Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Cell (Cambridge), Vol.110(6), pp.789-799
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0092-8674(02)00912-1
- PMID
- 12297051
- ISSN
- 0092-8674
- eISSN
- 1097-4172
- Language
- English
- Date published
- 2002
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020623802771
Metrics
22 Record Views