Journal article
Adenoviruses and enteroviruses as pathogens in myocarditis and dilated cardiomyopathy
Acta cardiologica, Vol.54(2), pp.83-88
1999
PMID: 10378019
Abstract
Background: Enteroviruses were detected in up to 50% in myocardium of patients with myocarditis and dilated cardiomyopathy, the latter being considered as a result of a prior subclinical myocarditis. A wide range of other infectious agents are being discussed as pathogens, often only based on reports of single cases. Adenovirus genome was recently identified in a significant number in the myocardium of paediatric patients with myocarditis. However, data on the role of adenoviruses for the aetiopathogenesis of myocarditis in adult patients is missing so far. Therefore, we studied the prevalence of adenoviral and enteroviral genome in myocardium of adults with myocarditis and dilated cardiomyopathy.
Methods: 15 patients were diagnosed at baseline with myocarditis, 16 patients with dilated cardiomyopathy according to clinical and histological criteria. Endomyocardial biopsies of these patients and 8 control patients with non-infectious heart diseases were evaluated by polymerase chain reactions for enterovirus and adenovirus genome.
Results: Enteroviral genome was detected in 27.3% patients with myocarditis or dilated cardiomyopathy, whereas adenoviral genome was not identified in any patient. Samples from control subjects systematically yielded negative results.
Conclusions: From our data, it seems doubtful that adenoviruses are major pathogens of myocarditis or DCM, whereas enterovirus genome was identified in a significant number of patients with both diseases.
Details
- Title: Subtitle
- Adenoviruses and enteroviruses as pathogens in myocarditis and dilated cardiomyopathy
- Creators
- I. M GRUMBACH - Division of Cardiology, Department of Internal Medicine, Georg-August-Universität, Göttingen, GermanyA HEIM - Department of Virology, Medizinische Hochschule Hannover, GermanyP PRING-AKERBLOM - Department of Virology, Medizinische Hochschule Hannover, GermanyS VONHOF - Division of Cardiology, Department of Internal Medicine, Georg-August-Universität, Göttingen, GermanyW. J HEIN - Division of Cardiology, Department of Internal Medicine, Georg-August-Universität, Göttingen, GermanyG MÜLLER - Division of Cardiology, Department of Internal Medicine, Georg-August-Universität, Göttingen, GermanyH. R FIGULLA - Division of Cardiology, Department of Internal Medicine, Georg-August-Universität, Göttingen, Germany
- Resource Type
- Journal article
- Publication Details
- Acta cardiologica, Vol.54(2), pp.83-88
- Publisher
- Acta cardiologica
- PMID
- 10378019
- ISSN
- 0001-5385
- eISSN
- 1784-973X
- Language
- English
- Date published
- 1999
- Academic Unit
- Cardiovascular Medicine; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984094745502771
Metrics
20 Record Views