Adipocyte Ceramides—The Nexus of Inflammation and Metabolic Disease

Bhagirath Chaurasia; Chad Lamar Talbot; Scott A. Summers

doi:10.3389/fimmu.2020.576347

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Adipocyte Ceramides—The Nexus of Inflammation and Metabolic Disease

Journal article

Open access

Peer reviewed

Adipocyte Ceramides—The Nexus of Inflammation and Metabolic Disease

Bhagirath Chaurasia, Chad Lamar Talbot and Scott A. Summers

Frontiers in immunology, Vol.11, pp.576347-576347

09/23/2020

DOI: 10.3389/fimmu.2020.576347

PMCID: PMC7538607

PMID: 33072120

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Abstract

Adipose depots are heterogeneous tissues that store and sense fuel levels. Through the secretion of lipids, cytokines, and protein hormones (adipokines), they communicate with other organ systems, informing them of the organism's nutritional status. The adipose tissues include diverse types of adipocytes (white, beige, and brown) distinguished by the number/size of lipid droplets, mitochondrial density, and thermogenic capacity. Moreover, they include a spectrum of immune cells that modulate metabolic activity and tissue remodeling. The unique characteristics and interplay of these cells control the production of ceramides, a class of nutrient signals derived from fat and protein metabolism that modulate adipocyte function to regulate glucose and lipid metabolism. The excessive accumulation of ceramides contributes to the adipose tissue inflammation and dysfunction that underlies cardiometabolic disease. Herein we review findings on this important class of lipid species and discuss their role at the convergence point that links overnutrition/inflammation to key features of the metabolic syndrome.

adipocyte

ceramide

diabetes

Immunology

inflammation

insulin

Details

Title: Subtitle: Adipocyte Ceramides—The Nexus of Inflammation and Metabolic Disease
Creators: Bhagirath Chaurasia - Roy J. and Lucille A. Carver College of Medicine
Chad Lamar Talbot - University of Utah
Scott A. Summers - University of Utah
Resource Type: Journal article
Publication Details: Frontiers in immunology, Vol.11, pp.576347-576347
DOI: 10.3389/fimmu.2020.576347
PMID: 33072120
PMCID: PMC7538607
NLM abbreviation: Front Immunol
ISSN: 1664-3224
eISSN: 1664-3224
Publisher: Frontiers Media S.A
Language: English
Date published: 09/23/2020
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984359574802771

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