Journal article
Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice
Biochemical and biophysical research communications, Vol.503(1), pp.264-270
09/03/2018
DOI: 10.1016/j.bbrc.2018.06.013
PMID: 29935181
Abstract
The maintenance of healthy adipose tissues is essential for efficient regulation of energy homeostasis. Nuclear factor-erythroid 2-related factor 1 (NFE2L1, also known as Nrf1), a CNC-bZIP protein, is a master regulator of the cellular adaptive response to stresses. To investigate the role of NFE2L1 in adipocytes, we bred a line of mice with adipocyte-specific Nfe2l1 knockout (Nfe2l1(f)-KO), and found that Nfe2l1(f)-KO mice exhibited a dramatically reduced subcutaneous adipose tissue (SAT) mass, insulin resistance, adipocyte hypertrophy, and severe adipose inflammation. Mechanistic studies revealed that Nfe2l1 deficiency may disturb the expression of lipolytic genes in adipocytes, leading to adipocyte hypertrophy followed by inflammation, pyroptosis, and insulin resistance. Our findings reveal a novel role for NFE2L1 in regulating adipose tissue plasticity and energy homeostasis.
•Nfe2l1(f)-KO mice exhibit diminished subcutaneous adipose tissues.•Nfe2l1(f)-KO mice show severe adipocyte hypertrophy and adipose inflammation.•Nfe2l1(f)-KO mice develop glucose intolerance and insulin resistance.
Details
- Title: Subtitle
- Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice
- Creators
- Yongyong Hou - China Medical UniversityZhiyuan Liu - China Medical UniversityZhuo Zuo - China Medical UniversityTianchang Gao - China Medical UniversityJingqi Fu - China Medical UniversityHuihui Wang - China Medical UniversityYuanyuan Xu - China Medical UniversityDianxin Liu - Sanford Burnham Prebys Medical Discovery InstituteMasayuki Yamamoto - Tohoku UniversityBeibei Zhu - University of KentuckyYiguo Zhang - Chongqing UniversityMelvin E. Andersen - Research Triangle Park FoundationQiang Zhang - Emory UniversityJingbo Pi - China Medical University
- Resource Type
- Journal article
- Publication Details
- Biochemical and biophysical research communications, Vol.503(1), pp.264-270
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.bbrc.2018.06.013
- PMID
- 29935181
- ISSN
- 0006-291X
- eISSN
- 1090-2104
- Grant note
- DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 81573106, 81402661; DOI: 10.13039/501100007300, name: China Medical University; name: Liaoning Pandeng Scholar
- Language
- English
- Date published
- 09/03/2018
- Academic Unit
- Neurology
- Record Identifier
- 9984302202302771
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