Journal article
Adipocytokines and achievement of low disease activity in rheumatoid arthritis
Seminars in arthritis and rheumatism, Vol.55, pp.152003-152003
08/2022
DOI: 10.1016/j.semarthrit.2022.152003
PMCID: PMC11000859
PMID: 35472662
Abstract
To determine if adipocytokines are independently associated with the achievement of low disease activity (LDA) over long-term follow-up in a large rheumatoid arthritis (RA) registry.
This cohort study evaluated adults with RA from the Veteran's Affairs RA Registry. Adipocytokines (adiponectin, leptin, and fibroblast growth factor [FGF]-21) and inflammatory cytokines were measured as part of a multi-analyte panel on banked serum from enrollment. Covariates were derived from medical record, biorepository, and registry databases. Multivariable Cox proportional hazard models evaluated associations between adipocytokines and rates of 1) DAS28 LDA and remission, 2) individual Boolean remission criteria and 3) initiation of a new bDMARD or tsDMARD.
There were 1,276 participants with a DAS28 >3.2 at enrollment. Of these, 827 achieved LDA and 598 achieved remission over 2,287 and 4,096 person-years, respectively. Patients in the highest quartile of adiponectin had lower rates LDA before and after adjustment [aHR Q4: 0.68 (0.53,0.87) p<0.001]. Those in the highest quartile of leptin and FGF-21 also had lower rates of LDA. Higher quartiles of adipocytokines were also associated with lower rates of achieving a low patient/evaluator global scores and low tender joint counts. Among 1,236 biologic-naïve participants, values above the median for adiponectin [HR: 1.67 (1.23,1.26) p = 0.001] and FGF-21 [HR: 1.27 (1.09,1.47) p = 0.002] were associated with a greater likelihood of initiating a b/tsDMARD.
Adipocytokines may serve as prognostic biomarkers of a more severe RA disease course. Additional study is needed to determine whether adipocytokines are phenotypic markers or whether they actively promote disease progression.
Details
- Title: Subtitle
- Adipocytokines and achievement of low disease activity in rheumatoid arthritis
- Creators
- Joshua F. Baker - University of PennsylvaniaBryant R. England - University of Nebraska Medical CenterMichael D. George - University of PennsylvaniaKatherine Wysham - VA Puget Sound Health Care SystemTate Johnson - University of Nebraska Medical CenterAleksander Lenert - Iowa City VA Health Care SystemGary Kunkel - University of UtahBrian Sauer - University of UtahMichael J. Duryee - University of Nebraska Medical CenterPaul Monach - VA Boston Healthcare SystemGail Kerr - Washington DC VA Medical CenterAndreas Reimold - VA North Texas Health Care SystemGeoffrey M. Thiele - University of Nebraska Medical CenterTed R. Mikuls - University of Nebraska Medical Center
- Resource Type
- Journal article
- Publication Details
- Seminars in arthritis and rheumatism, Vol.55, pp.152003-152003
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.semarthrit.2022.152003
- PMID
- 35472662
- PMCID
- PMC11000859
- ISSN
- 0049-0172
- eISSN
- 1532-866X
- Grant note
- DOI: 10.13039/100000738, name: US Department of Veterans Affairs; DOI: 10.13039/100000002, name: National Institutes of Health
- Language
- English
- Date published
- 08/2022
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984359785802771
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