Journal article
Adiposity and Interstitial Lung Abnormalities in Community-Dwelling Adults: The MESA Cohort Study
Chest, Vol.160(2), pp.582-594
08/2021
DOI: 10.1016/j.chest.2021.03.058
PMCID: PMC8411451
PMID: 33844978
Abstract
Obesity is associated with restrictive ventilatory defects and a faster rate of decline in FVC. This association is not exclusively mediated by mechanical factors and may reflect direct pulmonary injury by adipose-derived mediators.
Is adipose tissue involved in the pathogenesis of interstitial lung disease (ILD)?
We evaluated the association of CT measures of pericardial, abdominal visceral, and abdominal subcutaneous adipose tissue with high-attenuation areas (HAAs) and interstitial lung abnormalities (ILAs) in a large multicenter cohort study of community-dwelling adults, using multivariable-adjusted models. We secondarily evaluated the association of adipose depot size with FVC and biomarkers of obesity and inflammation.
In fully adjusted models, every doubling in pericardial adipose tissue volume was associated with a 63.4-unit increase in HAA (95% CI, 55.5-71.3), 20% increased odds of ILA (95% CI, -2% to 50%), and a 5.5% decrease in percent predicted FVC (95% CI, -6.8% to -4.3%). IL-6 levels accounted for 8% of the association between pericardial adipose tissue and HAA. Every doubling in visceral adipose tissue area was associated with a 41.5-unit increase in HAA (95% CI, 28.3-54.7), 30% increased odds of ILA (95% CI, -10% to 80%), and a 5.4% decrease in percent predicted FVC (95% CI, -6.6% to -4.3%). IL-6 and leptin accounted for 17% and 18%, respectively, of the association between visceral adipose tissue and HAA.
Greater amounts of pericardial and abdominal visceral adipose tissue were associated with CT measures of early lung injury and lower FVC in a cohort of community-dwelling adults. Adipose tissue may represent a modifiable risk factor for ILD.
Details
- Title: Subtitle
- Adiposity and Interstitial Lung Abnormalities in Community-Dwelling Adults: The MESA Cohort Study
- Creators
- Michaela R Anderson - Columbia University Medical CenterJohn S Kim - University of VirginiaMatthew Allison - University of California, San DiegoJon T Giles - Columbia University Medical CenterEric A Hoffman - University of IowaJingzhong Ding - Wake Forest UniversityR Graham Barr - Columbia University Irving Medical CenterAnna Podolanczuk - Cornell University
- Resource Type
- Journal article
- Publication Details
- Chest, Vol.160(2), pp.582-594
- DOI
- 10.1016/j.chest.2021.03.058
- PMID
- 33844978
- PMCID
- PMC8411451
- ISSN
- 0012-3692
- eISSN
- 1931-3543
- Grant note
- 75N95020D00007 / NIDA NIH HHS N01HC95169 / NHLBI NIH HHS N01HC95161 / NHLBI NIH HHS 75N99020D00007 / ORFDO NIH HHS 75N95020D00002 / NIDA NIH HHS N01HC95164 / NHLBI NIH HHS K23 HL150280 / NHLBI NIH HHS 75N90020D00003 / CLC NIH HHS N01HC95167 / NHLBI NIH HHS 75N98020D00007 / NIH HHS 75N90020D00002 / CLC NIH HHS N01HC95159 / NHLBI NIH HHS 75N96020D00002 / NIEHS NIH HHS 75N99020D00005 / ORFDO NIH HHS N01HC95163 / NHLBI NIH HHS 75N99020D00002 / ORFDO NIH HHS N01HC95166 / NHLBI NIH HHS UL1 TR001079 / NCATS NIH HHS 75N99020D00003 / ORFDO NIH HHS 75N95020D00005 / NIDA NIH HHS 75N93020D00002 / NIAID NIH HHS HHSN268201500003C / NHLBI NIH HHS N01HC95160 / NHLBI NIH HHS 75N99020D00006 / ORFDO NIH HHS 75N95020D00004 / NIDA NIH HHS L30 HL143645 / NHLBI NIH HHS HHSN268201500003I / NHLBI NIH HHS UL1 TR000040 / NCATS NIH HHS N01HC95168 / NHLBI NIH HHS K23 HL140199 / NHLBI NIH HHS 75N95020D00003 / NIDA NIH HHS 75N92021D00006 / NHLBI NIH HHS N01HC95165 / NHLBI NIH HHS 75N99020D00004 / ORFDO NIH HHS 75N96020D00003 / NIEHS NIH HHS N01HC95162 / NHLBI NIH HHS UL1 TR001420 / NCATS NIH HHS
- Language
- English
- Date published
- 08/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984318717802771
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