Journal article
Adjuvant therapy for resected extrahepatic cholangiocarcinoma: A review of the literature and future directions
Cancer treatment reviews, Vol.35(4), pp.322-327
2009
DOI: 10.1016/j.ctrv.2008.11.009
PMID: 19147294
Abstract
Cholangiocarcinoma is a rare neoplasm originating from the intra- or extrahepatic bile duct epithelium. Incidence has been increasing worldwide in the last three decades. Complete surgical resection provides the only possibility of cure, but even with resection 5-yr survival can be as low as 11%. Adjuvant therapy has the potential to play a crucial role in prolonging survival and local control. Retrospective series have suggested benefit to adjuvant radiation, chemotherapy or concurrent chemo-radiation. The scarce prospective data has not shown a survival benefit to adjuvant therapy. In this article we review and summarize the published data regarding adjuvant therapy for resected extrahepatic cholangiocarcinoma. Prospective, multi-institutional randomized trials are needed to clarify the role of adjuvant therapy in this disease.
Details
- Title: Subtitle
- Adjuvant therapy for resected extrahepatic cholangiocarcinoma: A review of the literature and future directions
- Creators
- Carryn Anderson - Department of Radiation Oncology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USARichard Kim - Section of Gastrointestinal Oncology, Taussig Cancer Center, 9500 Euclid Avenue, R-35, Cleveland, OH 44195, USA
- Resource Type
- Journal article
- Publication Details
- Cancer treatment reviews, Vol.35(4), pp.322-327
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.ctrv.2008.11.009
- PMID
- 19147294
- ISSN
- 0305-7372
- eISSN
- 1532-1967
- Language
- English
- Date published
- 2009
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984047652702771
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