Adolescent dairy product and calcium intake in relation to later prostate cancer risk and mortality in the NIH-AARP Diet and Health Study

Tuo Lan; Yikyung Park; Graham A Colditz; Jingxia Liu; Molin Wang; Kana Wu; Edward Giovannucci; Siobhan Sutcliffe

doi:10.1007/s10552-020-01330-z

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Adolescent dairy product and calcium intake in relation to later prostate cancer risk and mortality in the NIH-AARP Diet and Health Study

Journal article

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Adolescent dairy product and calcium intake in relation to later prostate cancer risk and mortality in the NIH-AARP Diet and Health Study

Tuo Lan, Yikyung Park, Graham A Colditz, Jingxia Liu, Molin Wang, Kana Wu, Edward Giovannucci and Siobhan Sutcliffe

Cancer causes & control, Vol.31(10), pp.891-904

10/2020

DOI: 10.1007/s10552-020-01330-z

PMID: 32743740

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https://www.ncbi.nlm.nih.gov/pmc/articles/7482419View

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Abstract

Purpose: Although a growing body of evidence supports an early-life contribution to prostate cancer (PCa) development, few studies have investigated early-life diet, and only three have examined early-life dairy product intake, a promising candidate risk factor because of its known/suspected influence on insulin-like growth factor levels and height. Methods: We used recalled dietary data from 162,816 participants in the NIH-AARP Diet and Health Study to investigate associations for milk, cheese, ice cream, total dairy, and calcium intake at ages 12-13 years with incident total (n = 17,729), advanced (n = 2,348), and fatal PCa (n = 827) over 14 years of follow-up. We calculated relative risks (RRs) and 95% confidence intervals (CIs) by Cox proportional hazards regression. Results: We observed suggestive positive trends for milk, dairy, and calcium intake with total and/or advanced PCa (p-trends = 0.016-0.148). These trends attenuated after adjustment for additional components of adolescent diet, particularly red meat and vegetables/potatoes. In contrast, suggestive inverse trends were observed for cheese and ice cream intake with total and/or advanced PCa (p-trends = 0.043-0.153), and for milk, dairy, and calcium intake with fatal PCa (p-trend = 0.045-0.117). Conclusion: Although these findings provide some support for a role of adolescent diet in increasing PCa risk, particularly for correlates of milk intake or overall dietary patterns, our protective findings for cheese and ice cream intake with PCa risk and mortality, and for all dairy products with PCa mortality, suggest alternative explanations, such as the influence of early-life socioeconomic status, and increased PCa screening, earlier detection, and better PCa care.

Details

Title: Subtitle: Adolescent dairy product and calcium intake in relation to later prostate cancer risk and mortality in the NIH-AARP Diet and Health Study
Creators: Tuo Lan
Yikyung Park
Graham A Colditz
Jingxia Liu
Molin Wang
Kana Wu
Edward Giovannucci
Siobhan Sutcliffe
Resource Type: Journal article
Publication Details: Cancer causes & control, Vol.31(10), pp.891-904
DOI: 10.1007/s10552-020-01330-z
PMID: 32743740
NLM abbreviation: Cancer Causes Control
ISSN: 0957-5243
eISSN: 1573-7225
Grant note: DOI: 10.13039/100014571, name: Alvin J. Siteman Cancer Center, award: NIH/NCI (P30 CA091842); name: the Institute for Clinical and Translational Sciences, award: NIH/NCATS (UL1 TR002345)
Language: English
Date published: 10/2020
Academic Unit: Occupational and Environmental Health
Record Identifier: 9984067699102771

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