Adolescent endogenous sex hormones and breast density in early adulthood

Seungyoun Jung; Brian L Egleston; D Walt Chandler; Linda Van Horn; Nola M Hylton; Catherine C Klifa; Norman L Lasser; Erin S LeBlanc; Kenneth Paris; John A Shepherd; Linda G Snetselaar; Frank Z Stanczyk; Victor J Stevens; Joanne F Dorgan

doi:10.1186/s13058-015-0581-4

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Adolescent endogenous sex hormones and breast density in early adulthood

Journal article

Open access

Adolescent endogenous sex hormones and breast density in early adulthood

Seungyoun Jung, Brian L Egleston, D Walt Chandler, Linda Van Horn, Nola M Hylton, Catherine C Klifa, Norman L Lasser, Erin S LeBlanc, Kenneth Paris, John A Shepherd, …

Breast cancer research : BCR, Vol.17(1), pp.77-77

06/04/2015

DOI: 10.1186/s13058-015-0581-4

PMCID: PMC4468804

PMID: 26041651

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Abstract

During adolescence the breasts undergo rapid growth and development under the influence of sex hormones. Although the hormonal etiology of breast cancer is hypothesized, it remains unknown whether adolescent sex hormones are associated with adult breast density, which is a strong risk factor for breast cancer. Percentage of dense breast volume (%DBV) was measured in 2006 by magnetic resonance imaging in 177 women aged 25-29 years who had participated in the Dietary Intervention Study in Children from 1988 to 1997. They had sex hormones and sex hormone-binding globulin (SHBG) measured in serum collected on one to five occasions between 8 and 17 years of age. Multivariable linear mixed-effect regression models were used to evaluate the associations of adolescent sex hormones and SHBG with %DBV. Dehydroepiandrosterone sulfate (DHEAS) and SHBG measured in premenarche serum samples were significantly positively associated with %DBV (all P trend ≤0.03) but not when measured in postmenarche samples (all P trend ≥0.42). The multivariable geometric mean of %DBV across quartiles of premenarcheal DHEAS and SHBG increased from 16.7 to 22.1 % and from 14.1 to 24.3 %, respectively. Estrogens, progesterone, androstenedione, and testosterone in pre- or postmenarche serum samples were not associated with %DBV (all P trend ≥0.16). Our results suggest that higher premenarcheal DHEAS and SHBG levels are associated with higher %DBV in young women. Whether this association translates into an increased risk of breast cancer later in life is currently unknown. ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.

Gonadal Steroid Hormones - metabolism

Humans

Risk Factors

Dehydroepiandrosterone Sulfate - metabolism

Sex Hormone-Binding Globulin - metabolism

Dehydroepiandrosterone Sulfate - blood

Gonadal Steroid Hormones - blood

Breast - metabolism

Magnetic Resonance Imaging

Adolescent

Breast Neoplasms - blood

Adult

Female

Breast - pathology

Child

Details

Title: Subtitle: Adolescent endogenous sex hormones and breast density in early adulthood
Creators: Seungyoun Jung - Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall 102E, Baltimore, MD, 21201, USA. sjung@epi.umaryland.edu
Brian L Egleston - Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA. Brian.Egleston@fccc.edu
D Walt Chandler - Esoterix Inc, 4301 Lost Hills Road, Calabasas Hills, CA, 91301, USA. Chandld@LabCorp.com
Linda Van Horn - Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL, 60611, USA. lvanhorn@northwestern.edu
Nola M Hylton - Department of Radiology, University of California, San Francisco, 500 Parnassus Avenue, San Francisco, CA, 94143, USA. Nola.Hylton@ucsf.edu
Catherine C Klifa - Dangeard Group, 580 W Remington Drive, San Francisco, CA, 94087, USA. catherine@klifa.net
Norman L Lasser - Department of Medicine, Rutgers New Jersey Medical School, 185 S Orange Avenue, Newark, NJ, 07103, USA. nlasser@verizon.net
Erin S LeBlanc - Kaiser Permanente Center for Health Research, 3800 N Interstate Avenue, Portland, OR, 97227, USA. Erin.S.LeBlanc@kpchr.org
Kenneth Paris - Department of Pediatrics, Louisiana State University School of Medicine, 1901 Perdido Street, New Orleans, LA, 70112, USA. kparis@lsuhsc.edu
John A Shepherd - Department of Radiology, University of California, San Francisco, 500 Parnassus Avenue, San Francisco, CA, 94143, USA. kparis@lsuhsc.edu
Linda G Snetselaar - Department of Epidemiology, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA. linda-snetselaar@uiowa.edu
Frank Z Stanczyk - Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, 1975 Zonal Avenue, Los Angeles, CA, 90033, USA. fstanczyk@att.net
Victor J Stevens - Kaiser Permanente Center for Health Research, 3800 N Interstate Avenue, Portland, OR, 97227, USA. victoria.stevens@cancer.org
Joanne F Dorgan - Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall 102E, Baltimore, MD, 21201, USA. jdorgan@som.umaryland.edu
Resource Type: Journal article
Publication Details: Breast cancer research : BCR, Vol.17(1), pp.77-77
DOI: 10.1186/s13058-015-0581-4
PMID: 26041651
PMCID: PMC4468804
NLM abbreviation: Breast Cancer Res
ISSN: 1465-5411
eISSN: 1465-542X
Publisher: England
Grant note: R01 CA116182 / NCI NIH HHS P30 CA134274 / NCI NIH HHS R01 CA104670 / NCI NIH HHS R03 CA167764 / NCI NIH HHS
Language: English
Date published: 06/04/2015
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983995111202771

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