Journal article
Adolescents and young adults (AYA) with cancer: the clinical course of COVID-19 infections
Journal of the National Cancer Institute, Vol.116(8), pp.1366-1373
08/2024
DOI: 10.1093/jnci/djae085
PMID: 38627241
Abstract
Adolescents and Young Adults (AYAs: 15-39 y) with cancer face unique vulnerabilities, yet remain under-represented on clinical trials, including adult registries of COVID-19 in cancer (AYAs: 8-12%). Thus, we leveraged the Pediatric Oncology COVID-19 Case Report (POCC) to examine the clinical course of COVID-19 among AYAs with cancer. POCC collects de-identified clinical and sociodemographic data regarding 0-39yo with cancer (AYAs = 37%) and COVID-19 from >100 institutions. Between 04/01/2020-11/28/2023, 191 older AYAs [22-39y] and 640 younger AYAs [15-21y] were captured. Older AYAs were less often hospitalized (p < .001), admitted to the intensive care unit (ICU, p = .02), and/or required respiratory support (p = .057). In multivariable analyses, older AYAs faced 80% lower odds of ICU admission but 2.3-times greater odds of changes to cancer-directed therapy. Unvaccinated patients had 5.4-times higher odds of ICU admission. Among AYAs with cancer, the COVID-19 course varies by age. These findings can inform pediatric/adult oncology teams surrounding COVID-19 management and prevention.
Details
- Title: Subtitle
- Adolescents and young adults (AYA) with cancer: the clinical course of COVID-19 infections
- Creators
- Julie A Wolfson - University of Alabama at BirminghamElizabeth S Davis - Boston Medical CenterAniket Saha - Prisma HealthIsaac Martinez - University of Alabama at BirminghamDavid McCall - The University of Texas MD Anderson Cancer CenterPrachi Kothari - Children's Hospital of PhiladelphiaJulienne Brackett - Texas Children's HospitalDavid S Dickens - University of IowaAlissa R Kahn - St. Joseph’s University Medical CenterCarla Schwalm - Bronson Methodist HospitalArchana Sharma - Rutgers, The State University of New JerseyJoshua Richman - University of Alabama at BirminghamBranko Cuglievan - The University of Texas MD Anderson Cancer CenterSmita Bhatia - University of Alabama at BirminghamChen Dai - University of Alabama at BirminghamJennifer M Levine - Center for Cancer and Blood DisordersEmily E Johnston - University of Alabama at BirminghamPOCC Consortium
- Resource Type
- Journal article
- Publication Details
- Journal of the National Cancer Institute, Vol.116(8), pp.1366-1373
- DOI
- 10.1093/jnci/djae085
- PMID
- 38627241
- NLM abbreviation
- J Natl Cancer Inst
- ISSN
- 0027-8874
- eISSN
- 1460-2105
- Publisher
- OXFORD UNIV PRESS INC
- Grant note
This study was supported by the Concern Foundation. The funder was not involved with collection, analysis, or interpretation of data; the funder was not involved in the writing of the manuscript nor the decision to submit the manuscript for publication. DAS:Although data are available upon request to authors, data availability is extremely limited according to the data use agreements between the coordinating center and participating sites.
- Language
- English
- Electronic publication date
- 04/16/2024
- Date published
- 08/2024
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984586460202771
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