Journal article
Adrenergic stimulation of inositol phosphate accumulation in tracheal epithelium
Journal of applied physiology (1985), Vol.66(1), pp.504-508
01/01/1989
DOI: 10.1152/jappl.1989.66.1.504
PMID: 2563726
Abstract
To determine whether inositol phosphates are important second messengers in the regulation of Cl- secretion by airway epithelia, we examined the relationship between inositol phosphate accumulation and Cl- secretion in response to adrenergic agonists. We found that epinephrine stimulated Cl- secretion and inositol phosphate accumulation with similar concentration dependence. Although isoproterenol stimulated Cl- secretion, there was no effect of beta-adrenergic receptor activation on inositol phosphate accumulation. In contrast, alpha 1-adrenergic receptor activation stimulated inositol phosphate accumulation but failed to induce Cl- secretion. Another Cl- secretagogue, prostaglandin E1, also failed to stimulate inositol phosphate accumulation. These data suggest that inositol phosphate accumulation is neither sufficient nor required for stimulation of Cl- secretion in cultured canine tracheal epithelial cells.
Details
- Title: Subtitle
- Adrenergic stimulation of inositol phosphate accumulation in tracheal epithelium
- Creators
- Thomas Bainbridge - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242Ross D Feldman - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242Michael J Welsh - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.66(1), pp.504-508
- DOI
- 10.1152/jappl.1989.66.1.504
- PMID
- 2563726
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Date published
- 01/01/1989
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020744202771
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