Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm

Vojtech Gabriel; Christopher Zdyrski; Dipak K. Sahoo; Abigail Ralston; Hannah Wickham; Agnes Bourgois-Mochel; Basant Ahmed; Maria M. Merodio; Karel Paukner; Pablo Piñeyro; Jamie Kopper; Eric W. Rowe; Jodi D. Smith; David Meyerholz; Amir Kol; Austin Viall; Mohamed Elbadawy; Jonathan P. Mochel; Karin Allenspach

doi:10.3390/ijms25020701

Back

Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm

Journal article

Open access

Peer reviewed

Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm

Vojtech Gabriel, Christopher Zdyrski, Dipak K. Sahoo, Abigail Ralston, Hannah Wickham, Agnes Bourgois-Mochel, Basant Ahmed, Maria M. Merodio, Karel Paukner, Pablo Piñeyro, …

International journal of molecular sciences, Vol.25(2), 701

01/05/2024

DOI: 10.3390/ijms25020701

PMCID: PMC10815683

PMID: 38255775

Files and links (1)

url

https://doi.org/10.3390/ijms25020701View

Published (Version of record) Open Access

Abstract

Preclinical biomedical research is limited by the predictiveness of in vivo and in vitro models. While in vivo models offer the most complex system for experimentation, they are also limited by ethical, financial, and experimental constraints. In vitro models are simplified models that do not offer the same complexity as living animals but do offer financial affordability and more experimental freedom; therefore, they are commonly used. Traditional 2D cell lines cannot fully simulate the complexity of the epithelium of healthy organs and limit scientific progress. The One Health Initiative was established to consolidate human, animal, and environmental health while also tackling complex and multifactorial medical problems. Reverse translational research allows for the sharing of knowledge between clinical research in veterinary and human medicine. Recently, organoid technology has been developed to mimic the original organ’s epithelial microstructure and function more reliably. While human and murine organoids are available, numerous other organoids have been derived from traditional veterinary animals and exotic species in the last decade. With these additional organoid models, species previously excluded from in vitro research are becoming accessible, therefore unlocking potential translational and reverse translational applications of animals with unique adaptations that overcome common problems in veterinary and human medicine.

Details

Title: Subtitle: Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm
Creators: Vojtech Gabriel - Iowa State University
Christopher Zdyrski
Dipak K. Sahoo - Iowa State University
Abigail Ralston
Hannah Wickham - Iowa State University
Agnes Bourgois-Mochel - Iowa State University
Basant Ahmed - Iowa State University
Maria M. Merodio
Karel Paukner - Institute of Clinical and Experimental Medicine
Pablo Piñeyro - Iowa State University
Jamie Kopper - Iowa State University
Eric W. Rowe - Iowa State University
Jodi D. Smith - Iowa State University
David Meyerholz - University of Iowa
Amir Kol - University of California, Davis
Austin Viall - University of California, Davis
Mohamed Elbadawy - University of Georgia
Jonathan P. Mochel - Iowa State University
Karin Allenspach - Iowa State University
Resource Type: Journal article
Publication Details: International journal of molecular sciences, Vol.25(2), 701
DOI: 10.3390/ijms25020701
PMID: 38255775
PMCID: PMC10815683
NLM abbreviation: Int J Mol Sci
ISSN: 1422-0067
eISSN: 1422-0067
Publisher: MDPI
Language: English
Date published: 01/05/2024
Academic Unit: Pathology
Record Identifier: 9984544952402771

Metrics

25 Record Views

17 Times Cited - Web of Science