Logo image
Adult Moyamoya Disease and Syndrome: Current Perspectives and Future Directions: A Scientific Statement From the American Heart Association/American Stroke Association
Journal article   Open access   Peer reviewed

Adult Moyamoya Disease and Syndrome: Current Perspectives and Future Directions: A Scientific Statement From the American Heart Association/American Stroke Association

Nestor R. Gonzalez, Sepideh Amin-Hanjani, Oh Young Bang, Christopher Coffey, Rose Du, Jorn Fierstra, Justin F. Fraser, Satoshi Kuroda, Gretchen E. Tietjen, Shadi Yaghi, …
Stroke (1970), Vol.54(10), pp.e465-e479
10/2023
DOI: 10.1161/STR.0000000000000443
url
https://doi.org/10.1161/STR.0000000000000443View
Published (Version of record) Open Access

Abstract

Adult moyamoya disease and syndrome are rare disorders with significant morbidity and mortality. A writing group of experts was selected to conduct a literature search, summarize the current knowledge on the topic, and provide a road map for future investigation. The document presents an update in the definitions of moyamoya disease and syndrome, modern methods for diagnosis, and updated information on pathophysiology, epidemiology, and both medical and surgical treatment. Despite recent advancements, there are still many unresolved questions about moyamoya disease and syndrome, including lack of unified diagnostic criteria, reliable biomarkers, better understanding of the underlying pathophysiology, and stronger evidence for treatment guidelines. To advance progress in this area, it is crucial to acknowledge the limitations and weaknesses of current studies and explore new approaches, which are outlined in this scientific statement for future research strategies.

Details

Logo image