Journal article
Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis
International journal of epidemiology, Vol.41(5), pp.1419-1433
10/01/2012
DOI: 10.1093/ije/dys086
PMCID: PMC3465767
PMID: 22825588
Abstract
Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.
Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.
Results For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.
Conclusion Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.
Details
- Title: Subtitle
- Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis
- Creators
- David Wormser - University of CambridgeEmanuele Di Angelantonio - University of CambridgeStephen Kaptoge - University of CambridgeAngela M. Wood - University of CambridgePei Gao - University of CambridgeQi Sun - Harvard UniversityGoeran Walldius - Karolinska InstitutetRandi Selmer - Norwegian Institute of Public HealthW. M. Monique VerschurenH. Bas Bueno-de-MesquitaGunnar Engstrom - Lund UniversityPaul M. Ridker - Brigham and Women's HospitalInger Njolstad - Univ Tromso, N-9001 Tromso, NorwayHiroyasu Iso - The University of OsakaIngar Holme - University of OsloSimona Giampaoli - Istituto Superiore di SanitàHugh Tunstall-Pedoe - University of DundeeJ. Michael Gaziano - Harvard UniversityEric Brunner - University College LondonFrank Kee - Queen's University BelfastAlberto Tosetto - San Bortolo Hosp, Vicenza, ItalyChrista Meisinger - Helmholtz Zentrum MünchenHermann Brenner - German Cancer Research CenterPierre Ducimetiere - InsermPeter H. Whincup - St George's, University of LondonRobert W. TippingIan Ford - University of GlasgowPeter Cremer - Ludwig-Maximilians-Universität MünchenAlbert Hofman - Erasmus University RotterdamLars Wilhelmsen - University of GothenburgRobert Clarke - University of OxfordIan H. de Boer - University of WashingtonJ. Wouter Jukema - Leiden UniversityAlejandro Marín IbañezDebbie A. Lawlor - University of BristolRalph B. D'Agostino - Boston UniversityBeatriz Rodriguez - University of Hawaii SystemEdoardo Casiglia - University of PaduaCoen D. A. Stehouwer - Maastricht UniversityLeon A. Simons - UNSW SydneyPaul J. Nietert - Medical University of South CarolinaElizabeth Barrett-Connor - University of California San DiegoDemosthenes B. Panagiotakos - Harokopio University of AthensCecilia Bjorkelund - University of GothenburgTimo E. Strandberg - University of OuluSylvia Wassertheil-Smoller - Yeshiva UniversityDan G. Blazer - Duke UniversityTom W. Meade - University of LondonLennart Welin - Lidkoping Hosp, Lidkoping, SwedenKurt Svardsudd - Uppsala UniversityMark Woodward - The University of SydneyAulikki Nissinen - Finnish Institute for Health and WelfareDaan Kromhout - Wageningen University & ResearchTorben Jorgensen - Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, DenmarkReijo S. Tilvis - University of HelsinkiJack M. Guralnik - University of Maryland, BaltimoreAnnika Rosengren - University of GothenburgJames O. Taylor - E Boston Neighborhood Hlth Ctr, E Boston, MA USAStefan Kiechl - Innsbruck Medical UniversityGilles R. Dagenais - Université LavalF. Gerry R. Fowkes - University of EdinburghRobert B. Wallace - University of IowaKay-Tee Khaw - University of CambridgeJonathan A. Shaffer - Columbia UniversityMarjolein Visser - Vrije Universiteit AmsterdamJussi Kauhanen - University of Eastern FinlandJukka T. Salonen - Analytical ServicesJohn Gallacher - College of American PathologistsYoav Ben-Shlomo - College of American PathologistsAkihiko KitamuraJohan Sundstrom - Uppsala UniversityPatrik Wennberg - Umeå UniversityYutaka Kiyohara - Kyushu UniversityMakoto Daimon - Yamagata UniversityAgustin Gomez de la Camara - Hosp 12 Octubre, Madrid, SpainJackie A. Cooper - University College LondonAltan Onat - Istanbul UniversityRichard Devereux - Cornell UniversityKenneth J. Mukamal - Harvard UniversityRachel DanknerMatthew W. Knuiman - The University of Western AustraliaCarlos J. Crespo - Portland State UniversityRon T. Gansevoort - University of GroningenUri Goldbourt - Sheba Medical CenterBorge G. Nordestgaard - University of CopenhagenJonathan E. Shaw - The Heart Research InstituteMichael Mussolino - National Institutes of HealthHidaeki Nakagawa - Kanazawa Medical UniversityAstrid Fletcher - University of LondonLewis H. Kuller - University of PittsburghRichard F. Gillum - Centers for Disease Control and PreventionVilmundur Gudnason - Iceland Heart Assoc, Reykjavik, IcelandGerd AssmannNicholas Wald - Queen Mary University of LondonPekka R. Jousilahti - Finnish Institute for Health and WelfarePhilip Greenland - Northwestern UniversityMaurizio Trevisan - Nevada System of Higher EducationHanno Ulmer - Innsbruck Medical UniversityAdam S. Butterworth - University of CambridgeAaron R. Folsom - University of MinnesotaGeorge Davey-Smith - University of BristolFrank B. Hu - Harvard UniversityJohn Danesh - University of CambridgeEmerging Risk Factors Collaboration
- Resource Type
- Journal article
- Publication Details
- International journal of epidemiology, Vol.41(5), pp.1419-1433
- DOI
- 10.1093/ije/dys086
- PMID
- 22825588
- PMCID
- PMC3465767
- NLM abbreviation
- Int J Epidemiol
- ISSN
- 0300-5771
- eISSN
- 1464-3685
- Publisher
- Oxford Univ Press
- Number of pages
- 15
- Grant note
- UK Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) UL1TR000062 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) National Institute of Health, Cambridge Biomedical Research Centre MC_U137686857 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) RG/07/008/23674 / British Heart Foundation G19/35 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission RG/08/014 / British Heart Foundation
- Language
- English
- Date published
- 10/01/2012
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363590302771
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