Journal article
Adult post-transplant lymphoproliferative disease in the liver graft in patients with recurrent hepatitis C
European journal of gastroenterology & hepatology, Vol.23(7), pp.559-565
07/01/2011
DOI: 10.1097/MEG.0b013e3283474ac9
PMID: 21555941
Abstract
Aim The aim of this study is to clarify the association between hepatitis C virus (HCV) infection and post-transplant lymphoproliferative disease (PTLD) in the liver allograft.
Methods Of the 933 adults who underwent liver transplantation (LT) between 1990 and 2005, 10 patients developed PTLD. Seven of the 10 patients that were HCV(+) (group 1) were compared with three HCV-negative recipients (group 2).
Results The mean time between LT and PTLD was 24.5 months. There were no differences between in Epstein-Barr virus antibody status or tumor lymphocyte subsets. In five of the seven HCV-positive recipients who developed PTLD, PTLD recurred preferentially in the liver allograft, whereas none of the three HCV-negative patients who developed PTLD did so in the liver (71.4 vs. 0%, respectively, P = 0.038). In all five patients with graft PTLD, HCV recurred within 12 months followed by PTLD. There were significant differences between groups 1 and 2 in mean lymphocyte infiltrate scores (6.0 +/- 2.1 vs. 2.0 +/- 0.7, P = 0.037), fibrosis stage (2.4 +/- 0.5 vs. 0.7 +/- 0.5, P = 0.029), and frequency of lymphoid follicles in portal areas (33.6 +/- 14.8% vs. 1.1 +/- 2.3%, P = 0.0002).
Conclusion When PTLD occurs in patients with HCV recurrence after LT, it does so preferentially in the liver allograft. Eur J Gastroenterol Hepatol 23:559-565 (c) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Details
- Title: Subtitle
- Adult post-transplant lymphoproliferative disease in the liver graft in patients with recurrent hepatitis C
- Creators
- Robin D. Kim - University of UtahTakahisa Fujikawa - Kokura Memorial HospitalShugo Mizuno - Univ Florida, Coll Med, Dept Surg, Div Transplantat, Gainesville, FL USAJason J. Schwartz - University of UtahJohn B. Sorensen - University of UtahAlan W. Hemming - Univ Florida, Coll Med, Dept Surg, Div Transplantat, Gainesville, FL USAShiro Fujita - Univ Florida, Coll Med, Dept Surg, Div Transplantat, Gainesville, FL USA
- Resource Type
- Journal article
- Publication Details
- European journal of gastroenterology & hepatology, Vol.23(7), pp.559-565
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/MEG.0b013e3283474ac9
- PMID
- 21555941
- ISSN
- 0954-691X
- eISSN
- 1473-5687
- Number of pages
- 7
- Language
- English
- Date published
- 07/01/2011
- Academic Unit
- Surgery
- Record Identifier
- 9984322955502771
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