Advanced Glycation End Products, a Potential Link between Psoriasis and Cardiovascular Disease: A Case-control Study

Tulin Ergun; Vildan Yazici; Dilek Yavuz; Dilek Seckin-Gencosmanoglu; Gulsen Ozen; Andac Salman; Haner Direskeneli; Nevsun Inanc

doi:10.4103/ijd.IJD_396_18

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Advanced Glycation End Products, a Potential Link between Psoriasis and Cardiovascular Disease: A Case-control Study

Journal article

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Advanced Glycation End Products, a Potential Link between Psoriasis and Cardiovascular Disease: A Case-control Study

Tulin Ergun, Vildan Yazici, Dilek Yavuz, Dilek Seckin-Gencosmanoglu, Gulsen Ozen, Andac Salman, Haner Direskeneli and Nevsun Inanc

Indian journal of dermatology, Vol.64(3), pp.201-206

05/01/2019

DOI: 10.4103/ijd.IJD_396_18

PMCID: PMC6537697

PMID: 31148858

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Abstract

Context: Advanced glycation end products (AGEs) promote oxidative stress and inflammation by altering structure and function of proteins. They are excessively produced mainly in hyperglycemia, chronic inflammation and are involved in the development of atherosclerosis and cardiovascular disease. Aims: The aim of this study was to investigate whether skin AGEs levels were increased and had relation to premature atherosclerosis in patients with psoriasis. Subjects and Methods: Fifty-two psoriasis patients and 20 healthy controls (HC) were included. AGEs were determined by skin autofluorescence (SAF) analysis. High-sensitive C-reactive protein (hsCRP) and carotid intima-media thickness (CIMT) were also investigated. Physical activity and dietary patterns were determined. Statistical Analysis Used: Fisher's exact test, two-sample t-tests, MannuWhitney-U test, Pearson correlation, Spearman correlation, and Wilcoxon test. Results: SAFs were increased in psoriasis patients (1.8 arbitrary units [AUs]) compared to that in HC (1.6 AUs) (P = 0.057). Median CIMT values of HC and psoriasis groups were 0.43 (0.28-0.79), and 0.59 (0.44-0.98) respectively and the differences were significant (P = 0.001); hsCRP levels were not different between groups. Conclusions: Skin AGE accumulation was found to have a correlation with CIMT in psoriasis patients providing evidence for the role of AGEs in premature atherosclerosis.

Dermatology

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Advanced Glycation End Products, a Potential Link between Psoriasis and Cardiovascular Disease: A Case-control Study
Creators: Tulin Ergun - Marmara University
Vildan Yazici - Gebze Med Pk Hosp, Dept Dermatol, Kocaeli, Turkey
Dilek Yavuz - Marmara University
Dilek Seckin-Gencosmanoglu - Marmara University
Gulsen Ozen - Marmara University
Andac Salman - Marmara University
Haner Direskeneli - Marmara University
Nevsun Inanc - Marmara University
Resource Type: Journal article
Publication Details: Indian journal of dermatology, Vol.64(3), pp.201-206
DOI: 10.4103/ijd.IJD_396_18
PMID: 31148858
PMCID: PMC6537697
NLM abbreviation: Indian J Dermatol
ISSN: 0019-5154
eISSN: 1998-3611
Publisher: Wolters Kluwer Medknow Publications
Number of pages: 6
Grant note: AG-23188; AG-09453 / Turkish Society of Dermatology
Language: English
Date published: 05/01/2019
Academic Unit: Internal Medicine
Record Identifier: 9984702821902771

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