Journal article
Advanced chronic obstructive pulmonary disease is associated with high levels of high-density lipoprotein cholesterol
The Journal of heart and lung transplantation, Vol.30(6), pp.674-678
2011
DOI: 10.1016/j.healun.2010.12.010
PMID: 21306919
Abstract
Chronic obstructive pulmonary disease (COPD) is an inflammatory systemic disease associated with numerous extrapulmonary manifestations. Amongst these is an increased risk for cardiovascular disease. The mechanisms for this association remain unclear. We sought to examine lipid trends in a well-characterized cohort of patients with severe COPD.
We conducted a retrospective prospective analysis of 126 consecutive individuals evaluated for lung transplantation with a diagnosis of COPD in whom lipid values were available. Observed lipid values were compared with a reference population without severe COPD.
Compared with the reference population, mean low-density lipoprotein cholesterol (LDL-C) levels were slightly reduced at 108 ± 44 vs 117 ± 29.5 mg/dl (
p = 0.02) in men but were no different in women. Mean high-density lipoprotein cholesterol (HDL-C) levels were significantly elevated at 62 ± 24 vs 45 ± 12 mg/dl (
p < 0.0001) in men and at 83 ± 27 vs 59 ± 16 mg/dl in women (
p < 0.0001). Prednisone use correlated with higher HDL-C levels but did not fully explain the extent of elevation. Angiographically proven coronary artery disease was found in 61% of individuals and was unrelated to HDL-C levels.
Severe COPD is associated with increased levels of HDL-C, which is partially attributable to oral steroid use. HDL-C in this population is not associated with reduced risk of angiographically proven coronary artery disease.
Details
- Title: Subtitle
- Advanced chronic obstructive pulmonary disease is associated with high levels of high-density lipoprotein cholesterol
- Creators
- Robert M Reed - Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MarylandAldo Iacono - Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MarylandAndrew DeFilippis - Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MarylandMichael Eberlein - Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MarylandReda E Girgis - Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MarylandSteven Jones - Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
- Resource Type
- Journal article
- Publication Details
- The Journal of heart and lung transplantation, Vol.30(6), pp.674-678
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.healun.2010.12.010
- PMID
- 21306919
- ISSN
- 1053-2498
- eISSN
- 1557-3117
- Language
- English
- Date published
- 2011
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984094623202771
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