Advances and gaps in SARS-CoV-2 infection models

César Muñoz-Fontela; Lina Widerspick; Randy A Albrecht; Martin Beer; Miles W Carroll; Emmie de Wit; Michael S Diamond; William E Dowling; Simon GP Funnell; Adolfo García-Sastre; Nora M Gerhards; Rineke de Jong; Vincent J Munster; Johan Neyts; Stanley Perlman; Douglas S Reed; Juergen A Richt; Ximena Riveros-Balta; Chad J Roy; Francisco J Salguero; Michael Schotsaert; Lauren M Schwartz; Robert A Seder; Joaquim Segalés; Seshadri S Vasan; Ana María Henao-Restrepo; Dan H Barouch

doi:10.1371/journal.ppat.1010161

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Advances and gaps in SARS-CoV-2 infection models

Journal article

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Peer reviewed

Advances and gaps in SARS-CoV-2 infection models

César Muñoz-Fontela, Lina Widerspick, Randy A Albrecht, Martin Beer, Miles W Carroll, Emmie de Wit, Michael S Diamond, William E Dowling, Simon GP Funnell, Adolfo García-Sastre, …

PLoS pathogens, Vol.18(1), e1010161

01/13/2022

DOI: 10.1371/journal.ppat.1010161

PMCID: PMC8757994

PMID: 35025969

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Abstract

The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age. status: Published online

Details

Title: Subtitle: Advances and gaps in SARS-CoV-2 infection models
Creators: César Muñoz-Fontela
Lina Widerspick - Bernhard Nocht Institute for Tropical Medicine
Randy A Albrecht - Emerging Pathogens Institute
Martin Beer - Friedrich-Loeffler-Institut
Miles W Carroll - Public Health England
Emmie de Wit - National Institute of Allergy and Infectious Diseases
Michael S Diamond - Washington University in St. Louis
William E Dowling - Coalition for Epidemic Preparedness Innovations
Simon GP Funnell - Public Health England
Adolfo García-Sastre - Emerging Pathogens Institute
Nora M Gerhards - Wageningen Bioveterinary Research, Lelystad, the Netherlands
Rineke de Jong - Wageningen Bioveterinary Research, Lelystad, the Netherlands
Vincent J Munster - National Institute of Allergy and Infectious Diseases
Johan Neyts - Rega Institute for Medical Research
Stanley Perlman - University of Iowa
Douglas S Reed - University of Pittsburgh
Juergen A Richt - Kansas State University
Ximena Riveros-Balta - World Health Organization - Pakistan
Chad J Roy - Tulane University
Francisco J Salguero
Michael Schotsaert
Lauren M Schwartz - World Health Organization - Pakistan
Robert A Seder - National Institutes of Health
Joaquim Segalés - Centre de Recerca en Sanitat Animal
Seshadri S Vasan - Australian Centre for Disease Preparedness
Ana María Henao-Restrepo - World Health Organization - Pakistan
Dan H Barouch - Beth Israel Deaconess Medical Center
Resource Type: Journal article
Publication Details: PLoS pathogens, Vol.18(1), e1010161
DOI: 10.1371/journal.ppat.1010161
PMID: 35025969
PMCID: PMC8757994
NLM abbreviation: PLoS Pathog
ISSN: 1553-7366
eISSN: 1553-7374
Language: English
Date published: 01/13/2022
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9984229997102771

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