Journal article
Advances in Molecular and Cellular Therapies for Hearing Loss
Molecular therapy, Vol.16(2), pp.224-236
02/2008
DOI: 10.1038/sj.mt.6300351
PMID: 18223547
Abstract
Development of effective therapeutics for hearing loss has proven to be a slow and difficult process, evidenced by the lack of restorative medicines and technologies currently available to the otolaryngologist. In large part this is attributable to the limited regenerative potential in cochlear cells and the secondary degeneration of the cochlear architecture that commonly follows sensorineural hearing impairment. Therapeutic advances have been made using animal models, particularly in regeneration and remodeling of spiral ganglion neurons, which retract and die following hair cell loss. Natural regeneration in avian and reptilian systems provides hope that replacement of hair cells is achievable in humans. The most exciting recent advancements in this field have been made in the relatively new areas of cellular replacement and gene therapy. In this review we discuss recent developments in gene- and cell-based therapy for hearing loss, including detailed analysis of therapeutic mechanisms such as RNA interference and stem cell transplantation, as well as in utero delivery to the mammalian inner ear. We explore the advantages and limitations associated with the use of these strategies for inner ear restoration.
Details
- Title: Subtitle
- Advances in Molecular and Cellular Therapies for Hearing Loss
- Creators
- Michael S Hildebrand - Department of Otolaryngology—Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USAStephen S Newton - Department of Otolaryngology—Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USASamuel P Gubbels - Department of Otolaryngology—Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USAAbraham M Sheffield - Department of Otolaryngology—Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USAAmit Kochhar - Department of Otolaryngology—Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USAMichelle G de Silva - Particulate Fluids Processing Centre, Department of Chemical and Biomolecular Engineering, University of Melbourne, Melbourne, Victoria, AustraliaHans-Henrik M Dahl - Murdoch Children's Research Institute, Royal Children's, Hospital, Melbourne, AustraliaScott D Rose - Integrated DNA Technologies, Coralville, Iowa, USAMark A Behlke - Integrated DNA Technologies, Coralville, Iowa, USARichard JH Smith - Department of Otolaryngology—Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Molecular therapy, Vol.16(2), pp.224-236
- DOI
- 10.1038/sj.mt.6300351
- PMID
- 18223547
- NLM abbreviation
- Mol Ther
- ISSN
- 1525-0016
- eISSN
- 1525-0024
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 02/2008
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006460202771
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