Journal article
Advances in the pathogenesis and treatment of IBD
Clinical immunology (Orlando, Fla.), Vol.132(1), pp.1-9
2009
DOI: 10.1016/j.clim.2009.02.006
PMID: 19321388
Abstract
Crohn's disease and ulcerative colitis are chronic remitting and relapsing inflammatory bowel diseases. We present a typical case of Crohn's disease in a young woman and discuss potential treatment options. Crohn's disease and ulcerative colitis likely result from interaction of multiple genetic and environmental risk and protective factors. Both are diseases ultimately caused by immune dysregulation. Medical therapy is with mesalamine compounds, corticosteroids, immunomodulators and/or biologics that target TNFα signaling or α4-integrin-mediated trafficking. Investigational agents include those targeted against other cytokines and costimulatory molecules or designed to promote immune regulation such as exposure to helminths which is a focus of this review.
Details
- Title: Subtitle
- Advances in the pathogenesis and treatment of IBD
- Creators
- Nicholas A Braus - Doris Duke Clinical Research Fellowship Program Carver College of Medicine, University of Iowa, Iowa City, IA, USADavid E Elliott - Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Clinical immunology (Orlando, Fla.), Vol.132(1), pp.1-9
- DOI
- 10.1016/j.clim.2009.02.006
- PMID
- 19321388
- NLM abbreviation
- Clin Immunol
- ISSN
- 1521-6616
- eISSN
- 1521-7035
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2009
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094624102771
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