Journal article
Advancing Lung Immunology Research An Official American Thoracic Society Workshop Report
American journal of respiratory cell and molecular biology, Vol.67(1), pp.E1-E18
07/01/2022
DOI: 10.1165/rcmb.2022-0167ST
PMCID: PMC9273224
PMID: 35776495
Abstract
The mammalian airways and lungs are exposed to a myriad of inhaled particulate matter, allergens, and pathogens. The immune system plays an essential role in protecting the host from respiratory pathogens, but a dysregulated immune response during respiratory infection can impair pathogen clearance and lead to immunopathology. Furthermore, inappropriate immunity to inhaled antigens can lead to pulmonary diseases. A complex network of epithelial, neural, stromal, and immune cells has evolved to sense and respond to inhaled antigens, including the decision to promote tolerance versus a rapid, robust, and targeted immune response. Although there has been great progress in understanding the mechanisms governing immunity to respiratory pathogens and aeroantigens, we are only beginning to develop an integrated understanding of the cellular networks governing tissue immunity within the lungs and how it changes after inflammation and over the human life course. An integrated model of airway and lung immunity will be necessary to improve mucosal vaccine design as well as prevent and treat acute and chronic inflammatory pulmonary diseases. Given the importance of immunology in pulmonary research, the American Thoracic Society convened a working group to highlight central areas of investigation to advance the science of lung immunology and improve human health.
Details
- Title: Subtitle
- Advancing Lung Immunology Research An Official American Thoracic Society Workshop Report
- Creators
- Rod A. Rahimi - Massachusetts General HospitalJosalyn L. Cho - Univ Iowa, Dept Internal Med, Carver Coll Med, Div Pulm Crit Care & Occupat Med, Iowa City, IA 52242 USAClaudia Jakubzick - Dartmouth CollegeShabaana A. Khader - Washington University in St. LouisBart N. Lambrecht - Ghent UniversityClare M. Lloyd - Wellcome TrustAri B. Molofsky - University of California, San FranciscoSebastien Talbot - Université de MontréalCatherine A. Bonham - University of VirginiaWonder P. Drake - Vanderbilt UniversityAnne Sperling - University of VirginiaBenjamin D. Singer - Northwestern University
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory cell and molecular biology, Vol.67(1), pp.E1-E18
- DOI
- 10.1165/rcmb.2022-0167ST
- PMID
- 35776495
- PMCID
- PMC9273224
- NLM abbreviation
- Am J Respir Cell Mol Biol
- ISSN
- 1044-1549
- eISSN
- 1535-4989
- Publisher
- Amer Thoracic Soc
- Number of pages
- 18
- Grant note
- DK043351 / NIH via Massachusetts General Hospital Center for the Study of Inflammatory Bowel Disease Pilot Feasibility Study 107059/Z/15/Z / Wellcome Trust Senior Fellowship in Basic Biomedical Science; Wellcome Trust University of Ghent Methusalem grant R01 AI125644; U19 AI162310; R21 AI149416; R01 HL149883; R01 HL153122; P01 AG049665; P01 HL154998; U19 AI135964; K08 HL140173; UH2 AI44434; R01 HL148758; R35 HL155458; R01 AI155024; R01 AI150043; R01 AI111914; R01AI123780; R01 AI134236; K23 HL143135; R01 HL142701 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Massachusetts General Hospital; General Electric 461275; 461274 / Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) Ellen Dreiling Research Fund ERC; European Research Council (ERC); European Commission EOS grant "BENEFICIARIES" 950-231859 / Canada Research Chair Program; Canada Research Chairs
- Language
- English
- Date published
- 07/01/2022
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984359823702771
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