Journal article
Advancing Prevention and Treatment of Ankle Osteoarthritis: A Translational Clinical Roadmap from the 2026 AOFAS/Arthritis Foundation Ankle Arthritis Think Tank
Foot & ankle orthopaedics, Vol.11(3), pp.1-14
07/2026
DOI: 10.1177/24730114261464607
PMID: 42602148
Abstract
Ankle osteoarthritis (OA) is predominantly post-traumatic in origin. It differs in important ways biologically, mechanically, and clinically from hip and knee OA. Despite recognition of its long-term burden, treatment strategies for ankle OA remain largely reactive and centered on end-stage reconstruction. The Arthritis Foundation and the American Orthopaedic Foot & Ankle Society (AOFAS) co-sponsored an Ankle Arthritis Think Tank to address this deficiency in Napa, CA, on January 22, 2026. The focus was to solve patient frustration of limited treatment options and relatively poor outcomes when comparing to hip and knee osteoarthritis. The 2026 meeting brought together a multidisciplinary group of scientists and clinicians to present our current related state of knowledge and to define translational research priorities capable of advancing prevention and treatment of ankle OA within the next decade. Four structured sessions addressed topics relating to ankle OA: (1) Biologic and Biomechanical Pathogenesis, (2) Diagnostic and Management Challenges, (3) Therapeutic Strategies, and (4) Research Methodology. A moderated closing discussion focused on identifying actionable and fundable research pathways. Session presentations and discussion are synthesized here into a unified review.
Details
- Title: Subtitle
- Advancing Prevention and Treatment of Ankle Osteoarthritis: A Translational Clinical Roadmap from the 2026 AOFAS/Arthritis Foundation Ankle Arthritis Think Tank
- Creators
- Jonathon D. Backus - Steadman ClinicLew C. Schon - Mercy Medical CenterWilliam R. Ledoux - VA Puget Sound Health Care SystemMitchell C. Coleman - University of IowaKelsey H. Collins - University of California, San FranciscoScott J. Ellis - Hospital for Special SurgeryAmy L. Lenz - University of UtahCesar de Cesar Netto - Duke University HospitalConstantine A. Demetracopoulos - Hospital for Special SurgeryNancy E. Lane - University of California, DavisJason M. Wilken - University of IowaAnnunziato Amendola - Duke University HospitalAnish R. Kadakia - Northwestern UniversityErik A. Wikstrom - University of North Carolina at Chapel HillKenneth J. Hunt - University of Colorado Anschutz Medical CampusBopha Chrea - University of IowaJudith F. Baumhauer - University of RochesterTodd O. McKinley - Indiana University – Purdue University IndianapolisMichelle McLeod - Arthritis FoundationDonald D. Anderson - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Foot & ankle orthopaedics, Vol.11(3), pp.1-14
- DOI
- 10.1177/24730114261464607
- PMID
- 42602148
- NLM abbreviation
- Foot Ankle Orthop
- ISSN
- 2473-0114
- eISSN
- 2473-0114
- Publisher
- SAGE Publications
- Language
- English
- Date published
- 07/2026
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Industrial and Systems Engineering; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9985218383402771
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