Adverse Housing and Neighborhood Conditions and Inflammatory Markers among Middle-Aged African Americans

Mario Schootman; Elena M. Andresen; Fredric D. Wolinsky; Theodore K. Malmstrom; John E. Morley; Douglas K. Miller

doi:10.1007/s11524-009-9426-8

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Adverse Housing and Neighborhood Conditions and Inflammatory Markers among Middle-Aged African Americans

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Adverse Housing and Neighborhood Conditions and Inflammatory Markers among Middle-Aged African Americans

Mario Schootman, Elena M. Andresen, Fredric D. Wolinsky, Theodore K. Malmstrom, John E. Morley and Douglas K. Miller

Journal of urban health, Vol.87(2), pp.199-210

03/01/2010

DOI: 10.1007/s11524-009-9426-8

PMCID: PMC2845834

PMID: 20186494

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Abstract

Adverse housing and neighborhood conditions are independently associated with an increased risk of various diseases and conditions. One possible explanation relates to systemic inflammation, which is associated with these adverse health outcomes. The authors investigated the association between housing and neighborhood conditions with inflammatory markers using data about 352 persons aged 49-65 years from the African American Health study. Participants were identified by a multistage random selection process in 2000 to 2001(response rate, 76%). Blood was analyzed for soluble cytokine receptors (interleukin-6, tumor necrosis factor alpha), C-reactive protein, and adiponectin. Neighborhood and housing characteristics consisted of five observed block face conditions (external appearance of the block on which the subject lived), four perceived neighborhood conditions, four observed housing conditions (home assessment by the interviewers rating the interior and exterior of the subject's building), and census-tract level poverty rate from the 2000 census. Differences in some inflammatory markers were found by age, gender, chronic conditions, and body mass index (all Bonferroni-adjusted p < 0.0034). There was no association between any of the housing/neighborhood conditions and the pro-inflammatory markers and potential associations between some housing/neighborhood conditions and adiponectin (p < 0.05, Bonferroni-adjusted p > 0.0034). Inflammation does not appear to be a mediator of the association between poor housing/neighborhood conditions and adverse health outcomes in middle-aged African Americans.

General & Internal Medicine

Life Sciences & Biomedicine

Medicine, General & Internal

Public, Environmental & Occupational Health

Science & Technology

Details

Title: Subtitle: Adverse Housing and Neighborhood Conditions and Inflammatory Markers among Middle-Aged African Americans
Creators: Mario Schootman - Washington University in St. Louis
Elena M. Andresen - University of Florida College of Public Health and Health Professions
Fredric D. Wolinsky - University of Iowa
Theodore K. Malmstrom - Saint Louis University
John E. Morley - Saint Louis University
Douglas K. Miller - Indiana University
Resource Type: Journal article
Publication Details: Journal of urban health, Vol.87(2), pp.199-210
DOI: 10.1007/s11524-009-9426-8
PMID: 20186494
PMCID: PMC2845834
NLM abbreviation: J Urban Health
ISSN: 1099-3460
eISSN: 1468-2869
Publisher: Springer Nature
Number of pages: 12
Grant note: AG-10436 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01AG010436 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Department of Veterans Affairs Medical Centers of Iowa City, IA, USA
Language: English
Date published: 03/01/2010
Academic Unit: Health Management and Policy
Record Identifier: 9984363635102771

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