Journal article
Adverse effects of single therapeutic doses of diazepam on performance in normal geriatric subjects: relationship to plasma concentrations
Psychopharmacology, Vol.84(3), pp.342-346
1984
DOI: 10.1007/BF00555210
PMID: 6440180
Abstract
Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administration. Significant impairments were found in response to all doses of diazepam. The maximum impairment occurred at 1 h, which coincided with the highest plasma concentration of the drug.
Details
- Title: Subtitle
- Adverse effects of single therapeutic doses of diazepam on performance in normal geriatric subjects: relationship to plasma concentrations
- Creators
- N PomaraB StanleyR BlockJ GuidoD RussR BerchouM StanleyD J GreenblattR E NewtonS Gershon
- Resource Type
- Journal article
- Publication Details
- Psychopharmacology, Vol.84(3), pp.342-346
- Publisher
- Germany
- DOI
- 10.1007/BF00555210
- PMID
- 6440180
- ISSN
- 0033-3158
- eISSN
- 1432-2072
- Language
- English
- Date published
- 1984
- Academic Unit
- Iowa Neuroscience Institute; Anesthesia
- Record Identifier
- 9984007196202771
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