Journal article
Adverse events among the elderly receiving chemotherapy for advanced non-small-cell lung cancer
Journal of clinical oncology, Vol.28(4), pp.620-627
02/01/2010
DOI: 10.1200/JCO.2009.23.8485
PMCID: PMC2815997
PMID: 20038726
Abstract
To describe chemotherapy use and adverse events (AEs) for advanced-stage, non-small-cell lung cancer (NSCLC) in community practice, including descriptions according to variation by age.
We interviewed patients with newly diagnosed, stages IIIB and IV NSCLC in the population-based cohort studied by the Cancer Care Outcomes Research and Surveillance Consortium, and we abstracted the patient medical records. AEs were medical events occurring during chemotherapy. Using logistic regression, we assessed the association between age and chemotherapy; with Poisson regression, we estimated event rate ratios and adjusted the analysis for age, sex, ethnicity, radiation therapy, stage, histology, and presence and grade of 27 comorbidities.
Of 1,371 patients, 58% (95% CI, 55% to 61%) received chemotherapy and 35% (95% CI, 32% to 38%) had AEs. After adjustment, 72% (95% CI, 65% to 79%) of those younger than 55 years and 47% (95% CI, 42% to 52%) of those age 75 years and older received chemotherapy. Platinum-based therapies were less common in the older-age groups. Pretreatment medical event rates were 18.6% for patients younger than 55 years and were only 9.2% for those age 75 years and older (adjusted rate ratio, 0.49; 95% CI, 0.26 to 0.91). In contrast, older adults were more likely to have AEs during chemotherapy. The adjusted rate ratios compared with age younger than 55 years were 1.70 for 65- to 74-year-olds (95% CI, 1.19 to 2.43) and 1.34 for those age 75 years and older (95% CI, 0.90 to 2.00).
Older patients who received chemotherapy had fewer pretherapy events than younger patients and were less likely to receive platinum-based regimens. Nevertheless, older patients had more adverse events during chemotherapy, independent of comorbidity. Potential implicit trade-offs between symptom management and treatment toxicity should be made explicit and additionally studied.
Details
- Title: Subtitle
- Adverse events among the elderly receiving chemotherapy for advanced non-small-cell lung cancer
- Creators
- Elizabeth A Chrischilles - Department of Epidemiology, University of Iowa, Iowa City, IA 52242, USA. e-chrischilles@uiowa.eduJane F PendergastKatherine L KahnRobert B WallaceDaniela C MogaDavid P HarringtonCatarina I KiefeJane C WeeksDee W WestS Yousuf ZafarRobert H Fletcher
- Resource Type
- Journal article
- Publication Details
- Journal of clinical oncology, Vol.28(4), pp.620-627
- DOI
- 10.1200/JCO.2009.23.8485
- PMID
- 20038726
- PMCID
- PMC2815997
- NLM abbreviation
- J Clin Oncol
- ISSN
- 0732-183X
- eISSN
- 1527-7755
- Publisher
- United States
- Grant note
- U01 CA093344 / NCI NIH HHS U01 A093326 / PHS HHS U01 CA093324 / NCI NIH HHS U01 CA093332 / NCI NIH HHS 5 U18 HS016094 / AHRQ HHS U01 CA093348 / NCI NIH HHS U18 HS016094 / AHRQ HHS U01 CA01013 / NCI NIH HHS U01 CA093329 / NCI NIH HHS
- Language
- English
- Date published
- 02/01/2010
- Academic Unit
- Pharmacy; Epidemiology; Biostatistics; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9983995104102771
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