Journal article
Adverse infant outcomes among women with sleep apnea or insomnia during pregnancy: A retrospective cohort study
Sleep health, Vol.9(1), pp.26-32
02/2023
DOI: 10.1016/j.sleh.2022.09.012
PMCID: PMC10881279
PMID: 36371381
Abstract
To evaluate whether sleep apnea or insomnia among pregnant people is associated with increased risk for adverse infant outcomes.
Retrospective cohort study
California
The sample included singleton live births. Sleep apnea and insomnia were defined based on ICD-9 and -10 codes. A referent group was selected using exact propensity score matching on maternal characteristics, obstetric factors, and infant factors among individuals without a sleep disorder.
Adverse infant outcomes were obtained from birth certificate, hospital discharge, and death records (eg, Apgar scores, neonatal intensive care unit (NICU) stay, infant death, long birth stay, etc.). Logistic regression was used to calculate odds of an adverse infant outcome by sleep disorder type.
Propensity-score matched controls were identified for 69.9% of the 3371 sleep apnea cases and 68.8% of the 3213 insomnia cases. Compared to the propensity-matched referent group, individuals with a diagnosis of sleep apnea (n = 2357) had infants who were more likely to have any adverse outcome, low 1-min Apgar scores, NICU stay, and an emergency room visit in the first year of life. Infants born to mothers with a diagnosis of insomnia (n = 2212) were at increased risk of few negative outcomes relative to the propensity matched referent group, with the exception of an emergency room visit.
In unadjusted analyses, infants born to individuals with a diagnosis of sleep apnea or insomnia were at increased risk of several adverse outcomes. These were attenuated when using propensity score matching, suggesting these associations were driven by other comorbidities.
Details
- Title: Subtitle
- Adverse infant outcomes among women with sleep apnea or insomnia during pregnancy: A retrospective cohort study
- Creators
- Jennifer N. Felder - University of California, San FranciscoRebecca J. Baer - University of California, San FranciscoLarry Rand - University of California, San FranciscoKelli K. Ryckman - University of IowaLaura Jelliffe-Pawlowski - University of California, San FranciscoAric A. Prather - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, California, USA
- Resource Type
- Journal article
- Publication Details
- Sleep health, Vol.9(1), pp.26-32
- DOI
- 10.1016/j.sleh.2022.09.012
- PMID
- 36371381
- PMCID
- PMC10881279
- NLM abbreviation
- Sleep Health
- ISSN
- 2352-7218
- eISSN
- 2352-7226
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: R01HL142051; DOI: 10.13039/100008069, name: University of California, San Francisco; DOI: 10.13039/100008460, name: National Center for Complementary and Integrative Health, award: K23AT009896
- Language
- English
- Electronic publication date
- 11/10/2022
- Date published
- 02/2023
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology
- Record Identifier
- 9984318360202771
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