Journal article
Aerobic exercise offsets endothelial dysfunction induced by repetitive consumption of sugar-sweetened beverages in young healthy men
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.319(1), pp.R11-R18
07/01/2020
DOI: 10.1152/ajpregu.00055.2020
PMID: 32401628
Abstract
Consumption of a single, sugar-sweetened beverage (SSB) impairs vascular endothelial function. Regular aerobic exercise improves endothelium-dependent vasodilation: however, it is unknown whether these beneficial effects persist with frequent SSB consumption. Therefore, the purpose of this study was twofold; we studied the effects of repetitive SSB consumption (75 g D-glucose, 3 times/day) for 1 wk (Glu, n = 13, 23 +/- 4 yr. 23.5 +/- 3.4 kg/m(2)) on endothelium-dependent vasodilation (FMI)). Then, in a separate cohort, we investigated whether 45 min of moderate-intensity aerobic exercise on five separate days offset the hypothesized decrease in FMD during the Glu protocol (Glu +Ex. n = 11. 21 +/- 3 yr. 23.8 +/- 2.4 kg/m(2)). Baseline, fasting [glucose] (P = 0.15). [insulin] (P = 0.25). %FMD (P = 0.48). absolute FMD (P = 0.66), and shear rate area under the curve (SRAUC: P = 0.82) were similar between groups. Following the interventions, fasting [glucose] (Glu: 94 +/- 6 to 92 +/- 6 mg/dL, Glu +Ex: 89 +/- 8 to 87 +/- 6 mg/dL, P = 0.74) and [insulin] (Glu: 11.3 +/- 6.2 to 11.8 +/- 8.9 mu U/mL, Glu+Ex: 8.7 +/- 2.9 to 9.4 +/- 3.2 mu U/mL. P = 0.89) were unchanged. %FMD was reduced in Glu (6.1 +/- 2.2 to 5.1 +/- 1.3%) and increased in Glu+ Ex (6.6 +/- 2.2 to 7.8 +/- 2.4%, P < 0.05 for both). SRAUC increased similarly in both Glu [17,715 +/- 8,275 to 22,922 +/- 4,808 arbitrary units (A.U.)] and Glu +Ex (18.216 +/- 4,516 to 21.666 +/- 5,392 A.U., main effect of time P < 0.05). When %FMD was adjusted for SRAUC, attenuation was observed in Glu (0.41 +/- 0.18 to 0.23 +/- 0.08%/s x 103, P < 0.05) but not Glu+Ex (0.38 +/- 0.14 to 0.38 +/- 0.13%/s x 103, P = 0.88). Despite unchanged fasting [glucose] and [insulin], repeated consumption of SSBs impaired conduit artery vascular endothelial function. Additionally, subjects who engaged in regular moderateintensity aerobic exercise did not demonstrate the same SSB-induced endothelial dysfunction. Collectively, these data suggest aerobic exercise may offset the deleterious effects of repetitive SSB consumption.
Details
- Title: Subtitle
- Aerobic exercise offsets endothelial dysfunction induced by repetitive consumption of sugar-sweetened beverages in young healthy men
- Creators
- Joshua M. Bock - University of IowaErika Iwamoto - Sapporo Medical UniversityJeffrey G. Horak - University of IowaAndrew J. Feider - University of IowaSatoshi Hanada - University of IowaDarren P. Casey - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.319(1), pp.R11-R18
- Publisher
- Amer Physiological Soc
- DOI
- 10.1152/ajpregu.00055.2020
- PMID
- 32401628
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Number of pages
- 8
- Grant note
- 1-16-ICTS-015 / American Diabetes Association
- Language
- English
- Date published
- 07/01/2020
- Academic Unit
- Anesthesia; Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984294953202771
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