Journal article
Aerobic fitness and glycemic variability in adolescents with type 1 diabetes
Endocrine practice, Vol.20(6), pp.566-570
06/2014
DOI: 10.4158/EP13211.OR
PMID: 24449660
Abstract
This study examines the association of fitness on glycemic variability (GV) in adolescents with type 1 diabetes mellitus (T1DM). GV has been associated with high frequency of hyper- and hypoglycemia.
Nineteen adolescents with T1DM, ages 14 to 19 years, underwent aerobic fitness testing to determine their maximal aerobic capacity (VO2 max). A continuous glucose monitoring (CGM) device was placed on each subject and worn for 3 to 5 days until a return visit when the subjects underwent a 1-hour treadmill exercise session. Mean amplitude of glycemic excursion (MAGE) was calculated from the CGM data collected between the 2 study visits. Metabolic equivalent (MET), a measure of accumulated metabolic workload during the exercise session, was also calculated.
Mean VO2 max was 46.6 ± 6.8 mL/kg/min, with a range of 34.8 to 57.0 mL/kg/min. Mean MET during the exercise session was 577.2 ± 102.4 and ranged from 354.3 to 716.2 METs. There was an inverse association between VO2 max and MAGE (r = -0.46; 95% confidence interval [CI], -0.01 to -0.76; P = .048). MET load and MAGE also had an inverse relationship (r = -0.48; 95% CI, -0.03 to -0.77; P = .037).
GV is inversely associated with fitness and MET load. Aerobic fitness should be promoted in adolescents with T1DM not only because of its multiple beneficial effects but also due to a possible association with GV, leading to fewer extremes in hypo- and hyperglycemia.
Details
- Title: Subtitle
- Aerobic fitness and glycemic variability in adolescents with type 1 diabetes
- Creators
- Ajay Singhvi - Department of Pediatric Endocrinology and Diabetes, University of Iowa Hospital and ClinicsMichael Jeremiah Tansey - Department of Pediatric Endocrinology and Diabetes, University of Iowa Hospital and ClinicsKathleen Janz - Health and Human Physiology, University of IowaMiriam Bridget Zimmerman - College of Public Health, University of Iowa, Iowa City, IowaEva Tsalikian - Department of Pediatric Endocrinology and Diabetes, University of Iowa Hospital and Clinics
- Resource Type
- Journal article
- Publication Details
- Endocrine practice, Vol.20(6), pp.566-570
- Publisher
- United States
- DOI
- 10.4158/EP13211.OR
- PMID
- 24449660
- ISSN
- 1530-891X
- eISSN
- 1934-2403
- Grant note
- UL1RR024979 / NCRR NIH HHS
- Language
- English
- Date published
- 06/2014
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics; Epidemiology; Biostatistics; Health and Human Physiology
- Record Identifier
- 9983997443502771
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