Aerosol deposition predictions in computed tomography-derived skeletons from severe asthmatics: A feasibility study

Shinjiro Miyawaki; Eric A Hoffman; Sally E Wenzel; Ching-Long Lin

doi:10.1016/j.clinbiomech.2017.10.020

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Aerosol deposition predictions in computed tomography-derived skeletons from severe asthmatics: A feasibility study

Journal article

Open access

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Aerosol deposition predictions in computed tomography-derived skeletons from severe asthmatics: A feasibility study

Shinjiro Miyawaki, Eric A Hoffman, Sally E Wenzel and Ching-Long Lin

Clinical biomechanics (Bristol), Vol.66, pp.81-87

06/2019

DOI: 10.1016/j.clinbiomech.2017.10.020

PMID: 29129332

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Abstract

The authors numerically investigated the correlation between airway skeletons of severe asthmatic human subjects and predicted aerosol deposition to shed light on the effect of environmental factors on asthma risk. We hypothesized that there are asthmatic subjects whose airway skeletal structure can expose the subject to a risk of higher local aerosol deposition compared to subjects with a more common/normal branching pattern. From a population of severe asthmatics studied at total lung capacity via computed tomography we randomly selected 8 subjects whose Forced Expiratory Volume in 1s, percent predicted fell below 45% predicted. To simulate aerosol motion in the human lungs, we employed in-house three-dimensional eddy-resolving computational fluid dynamics and particle tracking models utilizing 3 of the 8 severe asthmatic subjects. One of the 3 subjects was found to have a distinct, localized airway narrowing chosen for further investigation. In the simulation, we controlled flow rate and luminal area, i.e., Reynolds and Stokes numbers, in each branch of the computed tomography-derived airway skeletons. We found a distinct enhancement of aerosol deposition associated with the narrowed branches of one subject even when the luminal area was numerically adjusted from its narrowed state to that of a non-asthmatic subject. The branching angle, freed of luminal narrowing persisted in demonstrating a marginally significant increase in local particle deposition compared with the subjects without the initial constriction. These results demonstrate the possibility that inherent airway structure may influence localized constriction found in severe asthmatics.

Luminal area

Branching angle

Subject-specific

Geometric airway model

Numerical aerosol model

Details

Title: Subtitle: Aerosol deposition predictions in computed tomography-derived skeletons from severe asthmatics: A feasibility study
Creators: Shinjiro Miyawaki - IIHR-Hydroscience & Engineering, The University of Iowa, Iowa City, IA 52242, USA
Eric A Hoffman - Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA
Sally E Wenzel - Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
Ching-Long Lin - IIHR-Hydroscience & Engineering, The University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Clinical biomechanics (Bristol), Vol.66, pp.81-87
DOI: 10.1016/j.clinbiomech.2017.10.020
PMID: 29129332
NLM abbreviation: Clin Biomech (Bristol)
ISSN: 0268-0033
eISSN: 1879-1271
Publisher: Elsevier Ltd
Grant note: DOI: 10.13039/100000002, name: NIH, award: U01-HL114494, R01-HL094315, R01-HL112986, R01-HL69174, CTSI-RR024153, U01-HL209152, S10-RR022421
Language: English
Date published: 06/2019
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering; Internal Medicine
Record Identifier: 9984051581802771

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