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Affective disorder not linked to HLA in a large bipolar kindred
Journal article   Peer reviewed

Affective disorder not linked to HLA in a large bipolar kindred

Jan Campbell, Raymond R Crowe, Nancy Goeken, Bruce Pfohl, David Pauls and Dolores Palmer
Journal of affective disorders, Vol.7(1), pp.45-51
1984
DOI: 10.1016/0165-0327(84)90063-6
PMID: 6236243

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Abstract

Recent studies have suggested genetic linkage between the major histocompatibility complex and affective disorder. We tested this hypothesis in a large pedigree of bipolar affective disorder in which 22 of 37 relatives were interviewed and HLA typing was carried out on 20. The findings provided no evidence for linkage between affective disorder and HLA antigens. Our findings are discussed along with those of other linkage studies bearing on this question.
Genetics Kindred Bipolar affective disorder HLA typing

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