Affective illness in family members and matched controls

E Nelson; J Rice; N Rochberg; J Endicott; W Coryell; H S Akiskal

doi:10.1111/j.1600-0447.1995.tb09757.x

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Affective illness in family members and matched controls

Journal article

Peer reviewed

Affective illness in family members and matched controls

E Nelson, J Rice, N Rochberg, J Endicott, W Coryell and H S Akiskal

Acta psychiatrica Scandinavica, Vol.91(3), pp.146-151

03/1995

DOI: 10.1111/j.1600-0447.1995.tb09757.x

PMID: 7625186

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Abstract

As part of the US National Institute of Mental Health Collaborative Program on the Psychobiology of Depression study, a subset of 460 randomly chosen relatives of affectively ill probands were compared to a control group matched by the acquaintanceship method. The rate of major affective disorder in relatives was found to be 36%; the rate among controls was 28%. Relatives were also found to have significantly higher rates of bipolar II disorder, any Research Diagnostic Criteria (RDC) affective disorder and any RDC mental disorder. All of these rates were found to be significantly higher when female relatives were compared with their acquaintances, but only the rate of any RDC mental disorder was higher when this comparison was made in men. The acquaintanceship method enabled the selection of a control group that closely resembled the relatives, probably to the extent of "overmatching". When the match was evaluated to determine whether relatives tended to select comparably ill (or well) acquaintances, this was found to be the case only for alcoholic and never mentally ill relatives.

Phenotype

Depressive Disorder - genetics

Psychiatric Status Rating Scales - statistics & numerical data

Psychotic Disorders - diagnosis

Humans

Middle Aged

Psychotic Disorders - psychology

Risk Factors

Depressive Disorder - diagnosis

Male

Psychometrics

Alcoholism - diagnosis

Bipolar Disorder - diagnosis

Bipolar Disorder - genetics

Sampling Studies

Bipolar Disorder - psychology

Psychotic Disorders - genetics

Personality Assessment - statistics & numerical data

Selection Bias

Adult

Alcoholism - genetics

Female

Depressive Disorder - psychology

Alcoholism - psychology

Details

Title: Subtitle: Affective illness in family members and matched controls
Creators: E Nelson - Washington University School of Medicine, Department of Psychiatry, St. Louis, MO 63110, USA
J Rice
N Rochberg
J Endicott
W Coryell
H S Akiskal
Resource Type: Journal article
Publication Details: Acta psychiatrica Scandinavica, Vol.91(3), pp.146-151
Publisher: United States
DOI: 10.1111/j.1600-0447.1995.tb09757.x
PMID: 7625186
ISSN: 0001-690X
eISSN: 1600-0447
Language: English
Date published: 03/1995
Academic Unit: Psychiatry
Record Identifier: 9984003452302771

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