Aflatoxin B1 metabolism in the rat: Polyhalogenated biphenyl enhanced conversion to aflatoxin M1

E. C Shepherd; T. D Phillips; T. Rick Irvin; S. H Safe; L. W Robertson

doi:10.3109/00498258409151472

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Aflatoxin B1 metabolism in the rat: Polyhalogenated biphenyl enhanced conversion to aflatoxin M1

Journal article

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Aflatoxin B1 metabolism in the rat: Polyhalogenated biphenyl enhanced conversion to aflatoxin M1

E. C Shepherd, T. D Phillips, T. Rick Irvin, S. H Safe and L. W Robertson

Xenobiotica, Vol.14(9), pp.741-750

1984

DOI: 10.3109/00498258409151472

PMID: 6097059

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Abstract

1. The effects of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs) on the formation in vitro of aflatoxin Q1 and aflatoxin M1 from aflatoxin B1 by rat-liver microsomes were investigated. 2. AFB1 metabolism by hepatic microsomes from PBB- and PCB-treated rats resulted in 16- and 30-fold increases, respectively, in levels of aflatoxin M1. The enhanced formation of aflatoxin M1 did not correlate with PBB and PCB stimulation of benzo[a]pyrene hydroxylase (AHH) activity. 3. Studies in vivo clearly demonstrated enhanced secretion of aflatoxin M1 by female lactating rats with prior exposure to PCBs. PCB pretreatment enhanced the activity of mammary as well as hepatic tissue microsomal preparations in converting aflatoxin B1 to aflatoxin M1. 4. Our findings indicate that PCB exposure increases the production of aflatoxin M1 in vitro and also increases the levels of aflatoxin M1 released into the milk.

Details

Title: Subtitle: Aflatoxin B1 metabolism in the rat: Polyhalogenated biphenyl enhanced conversion to aflatoxin M1
Creators: E. C Shepherd - 1Department of Veterinary Public Health, Texas A&M University, College Station, TX, 77843, USA
T. D Phillips - 1Department of Veterinary Public Health, Texas A&M University, College Station, TX, 77843, USA
T. Rick Irvin - 1Department of Veterinary Public Health, Texas A&M University, College Station, TX, 77843, USA
S. H Safe - 2Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77843, USA
L. W Robertson - 2Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77843, USA
Resource Type: Journal article
Publication Details: Xenobiotica, Vol.14(9), pp.741-750
DOI: 10.3109/00498258409151472
PMID: 6097059
NLM abbreviation: Xenobiotica
ISSN: 0049-8254
eISSN: 1366-5928
Publisher: Informa UK Ltd
Language: English
Date published: 1984
Academic Unit: Occupational and Environmental Health
Record Identifier: 9984002330702771

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