Journal article
After Bone Marrow Transplantation, the Cell-Intrinsic Th2 Pathway Promotes Recipient T Lymphocyte Survival and Regulates Graft-versus-Host Disease
ImmunoHorizons, Vol.7(6), pp.442-455
06/01/2023
DOI: 10.4049/immunohorizons.2300021
PMCID: PMC10580113
PMID: 37294277
Abstract
Recipient T cells can aggravate or regulate lethal and devastating graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In this context, we have shown before that intestinal immune conditioning with helminths is associated with survival of recipient T cells and Th2 pathway–dependent regulation of GVHD. We investigated the mechanism of survival of recipient T cells and their contribution to GVHD pathogenesis in this helminth infection and BMT model after myeloablative preparation with total body irradiation in mice. Our results indicate that the helminth-induced Th2 pathway directly promotes the survival of recipient T cells after total body irradiation. Th2 cells also directly stimulate recipient T cells to produce TGF-β, which is required to regulate donor T cell–mediated immune attack of GVHD and can thereby contribute to recipient T cell survival after BMT. Moreover, we show that recipient T cells, conditioned to produce Th2 cytokines and TGF-β after helminth infection, are fundamentally necessary for GVHD regulation. Taken together, reprogrammed or immune-conditioned recipient T cells after helminth infection are crucial elements of Th2- and TGF-β–dependent regulation of GVHD after BMT, and their survival is dependent on cell-intrinsic Th2 signaling.
Details
- Title: Subtitle
- After Bone Marrow Transplantation, the Cell-Intrinsic Th2 Pathway Promotes Recipient T Lymphocyte Survival and Regulates Graft-versus-Host Disease
- Creators
- Jamie Truscott - University of IowaXiaoqun Guan - University of IowaHope Fury - University of IowaTyler Atagozli - University of IowaAhmed Metwali - University of IowaWeiren Liu - University of IowaYue Li - University of IowaRobert W Li - United States Department of AgricultureDavid E Elliott - University of IowaBruce R Blazar - University of MinnesotaM Nedim Ince - University of Iowa
- Resource Type
- Journal article
- Publication Details
- ImmunoHorizons, Vol.7(6), pp.442-455
- DOI
- 10.4049/immunohorizons.2300021
- PMID
- 37294277
- PMCID
- PMC10580113
- NLM abbreviation
- Immunohorizons
- eISSN
- 2573-7732
- Language
- English
- Date published
- 06/01/2023
- Academic Unit
- Gastroenterology and Hepatology; Biology; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984430332202771
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