Journal article
AgNOR count as objective marker for dysplastic features in oral leukoplakia
Journal of oral pathology & medicine, Vol.31(9), pp.512-517
10/2002
DOI: 10.1034/j.1600-0714.2002.00153.x
PMID: 12269989
Abstract
Dysplasia is an important feature of leukoplakia. Because agreement among oral pathologists is poor regarding lesional diagnosis, silver stainable nucleolar organizer regions (AgNORs) as replicatory markers may have a place in objectively characterizing dysplasia in tissue specimens. We studied 41 normal oral epithelia, 51 oral leukoplakia (26 dysplastic, 25 non-dysplastic), and 51 cases of squamous cell carcinoma specimens for their mean AgNOR counts. Mean AgNOR counts increased gradually from normal epithelium to non-dysplastic to dysplastic leukoplakia to squamous cell carcinoma. Using ROC analysis, we determined a mean AgNOR count cut-point (2.37) that can be used to distinguish between dysplastic and non-dysplastic leukoplakia. The test had a sensitivity of 75% and specificity of 83% with area under the curve being 88%. Mean AgNOR count could be a valuable criterion for defining objective parameters for diagnosis/determination of dysplasia distinguishing between dysplastic and non-dysplastic leukoplakia.
Details
- Title: Subtitle
- AgNOR count as objective marker for dysplastic features in oral leukoplakia
- Creators
- Amit Chattopadhyay - Department of Dental Ecology, School of Dentistry and Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, USA. pretatma@hotmail.comJay G RayDaniel J Caplan
- Resource Type
- Journal article
- Publication Details
- Journal of oral pathology & medicine, Vol.31(9), pp.512-517
- Publisher
- Denmark
- DOI
- 10.1034/j.1600-0714.2002.00153.x
- PMID
- 12269989
- ISSN
- 0904-2512
- eISSN
- 1600-0714
- Language
- English
- Date published
- 10/2002
- Academic Unit
- Preventive and Community Dentistry
- Record Identifier
- 9983917669602771
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