AgRP neurons encode circadian feeding time

Nilufer Sayar-Atasoy; Iltan Aklan; Yavuz Yavuz; Connor Laule; Hyojin Kim; Jacob Rysted; Muhammed Ikbal Alp; Debbie Davis; Bayram Yilmaz; Deniz Atasoy

doi:10.1038/s41593-023-01482-6

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AgRP neurons encode circadian feeding time

Journal article

Peer reviewed

AgRP neurons encode circadian feeding time

Nilufer Sayar-Atasoy, Iltan Aklan, Yavuz Yavuz, Connor Laule, Hyojin Kim, Jacob Rysted, Muhammed Ikbal Alp, Debbie Davis, Bayram Yilmaz and Deniz Atasoy

Nature neuroscience, Vol.27(1), pp.102-115

01/2024

DOI: 10.1038/s41593-023-01482-6

PMCID: PMC11657780

PMID: 37957320

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https://pmc.ncbi.nlm.nih.gov/articles/PMC11657780/pdf/nihms-2036653.pdfView

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Abstract

Food intake follows a predictable daily pattern and synchronizes metabolic rhythms. Neurons expressing agouti-related protein (AgRP) read out physiological energetic state and elicit feeding, but the regulation of these neurons across daily timescales is poorly understood. Using a combination of neuron dynamics measurements and timed optogenetic activation in mice, we show that daily AgRP-neuron activity was not fully consistent with existing models of homeostatic regulation. Instead of operating as a 'deprivation counter', AgRP-neuron activity primarily followed the circadian rest-activity cycle through a process that required an intact suprachiasmatic nucleus and synchronization by light. Imposing novel feeding patterns through time-restricted food access or periodic AgRP-neuron stimulation was sufficient to resynchronize the daily AgRP-neuron activity rhythm and drive anticipatory-like behavior through a process that required DMHPDYN neurons. These results indicate that AgRP neurons integrate time-of-day information of past feeding experience with current metabolic needs to predict circadian feeding time.

Details

Title: Subtitle: AgRP neurons encode circadian feeding time
Creators: Nilufer Sayar-Atasoy
Iltan Aklan - University of Iowa
Yavuz Yavuz - Yeditepe University
Connor Laule - University of Iowa
Hyojin Kim - University of Iowa
Jacob Rysted - University of Iowa
Muhammed Ikbal Alp
Debbie Davis
Bayram Yilmaz
Deniz Atasoy - University of Iowa
Resource Type: Journal article
Publication Details: Nature neuroscience, Vol.27(1), pp.102-115
DOI: 10.1038/s41593-023-01482-6
PMID: 37957320
PMCID: PMC11657780
NLM abbreviation: Nat Neurosci
ISSN: 1097-6256
eISSN: 1546-1726
Language: English
Electronic publication date: 11/13/2023
Date published: 01/2024
Academic Unit: Neurology; Pathology; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology
Record Identifier: 9984508859202771

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