Journal article
Age- and sex-specific fear conditioning deficits in mice lacking Pcdh10, an Autism Associated Gene
Neurobiology of learning and memory, Vol.178, pp.107364-107364
02/2021
DOI: 10.1016/j.nlm.2020.107364
PMID: 33340671
Abstract
•PCDH10 is a gene associated with Autism Spectrum Disorder.•Pcdh10+/- juvenile and adult males exhibited cued fear conditioning deficits.•Pcdh10+/- juvenile and adult males exhibited contextual fear conditioning deficits.•Pcdh10+/- females were only impaired as adults in cued fear memory.
PCDH10 is a gene associated with Autism Spectrum Disorder. It is involved in the growth of thalamocortical projections and dendritic spine elimination. Previously, we characterized Pcdh10 haploinsufficient mice (Pcdh10+/- mice) and found male-specific social deficits and dark phase hypoactivity. Pcdh10+/- males exhibit increased dendritic spine density of immature morphology, decreased NMDAR expression, and decreased gamma synchronization in the basolateral amygdala (BLA). Here, we further characterize Pcdh10+/- mice by testing for fear memory, which relies on BLA function. We used both male and female Pcdh10+/- mice and their wild-type littermates at two ages, juvenile and adult, and in two learning paradigms, cued and contextual fear conditioning. We found that males at both ages and in both assays exhibited fear conditioning deficits, but females were only impaired as adults in the cued condition. These data are further evidence for male-specific alterations in BLA-related behaviors in Pcdh10+/- mice and suggest that these mice may be a useful model for dissecting male specific brain and behavioral phenotypes relevant to social and emotional behaviors.
Details
- Title: Subtitle
- Age- and sex-specific fear conditioning deficits in mice lacking Pcdh10, an Autism Associated Gene
- Creators
- Sarah L Ferri - Iowa Neuroscience Institute, Department of Neuroscience and Pharmacology, University of Iowa, 169 Newton Road, 2312 Pappajohn Biomedical Discovery Building, Iowa City, IA 52242, USAHolly C Dow - Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Translational Research Laboratory, 125 South 31st Street, Room 2202, Philadelphia, PA 19104-3403, USAHannah Schoch - Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, 412 E. Spokane Falls Blvd., Spokane, WA, 99202, USAJi Youn Lee - Iowa Neuroscience Institute, Department of Neuroscience and Pharmacology, University of Iowa, 169 Newton Road, 2312 Pappajohn Biomedical Discovery Building, Iowa City, IA 52242, USAEdward S Brodkin - Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Translational Research Laboratory, 125 South 31st Street, Room 2202, Philadelphia, PA 19104-3403, USATed Abel - Iowa Neuroscience Institute, Department of Neuroscience and Pharmacology, University of Iowa, 169 Newton Road, 2312 Pappajohn Biomedical Discovery Building, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Neurobiology of learning and memory, Vol.178, pp.107364-107364
- DOI
- 10.1016/j.nlm.2020.107364
- PMID
- 33340671
- NLM abbreviation
- Neurobiol Learn Mem
- ISSN
- 1074-7427
- eISSN
- 1095-9564
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100006920, name: University of Pennsylvania; DOI: 10.13039/100008893, name: University of Iowa; DOI: 10.13039/100000025, name: National Institute of Mental Health; DOI: 10.13039/100004897, name: Pennsylvania Department of Health
- Language
- English
- Date published
- 02/2021
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Developmental and Behavioral Pediatrics; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984070293902771
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